96245-97-5

Basic information

• Product Name: 2(1H)-Pyridinone, 3-bromo-4-hydroxy-
• Synonyms: 2(1H)-Pyridinone, 3-bromo-4-hydroxy-;2(1H)-Pyridone, 3-bromo-4-hydroxy- (6CI);2,4-Dihydroxy-3-bromopyridine;3-Bromo-2,4-pyridinediol;3-Bromo-4-hydroxy-2(1H)-pyridinone;3-Bromo-4-hydroxy-2(1H)-pyridone;bis(3-broMo-4-hydroxy-1,2-dihydropyridin-2-one);bis(3-broMopyridine-2,4-diol)
• CAS NO: 96245-97-5
• Molecular Formula: C₅H₄BrNO₂
• Molecular Weight: 190
• EINECS: 251-156-6
• Mol File: 96245-97-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 263.5-264.5 °C (decomp)
• Boiling Point: 263.5ºC at 760 mmHg
• Flash Point: 113.2ºC
• Appearance: /
• Density: 2.044g/cm3
• Vapor Pressure: 0.00144mmHg at 25°C
• Refractive Index: 1.68
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 2(1H)-Pyridinone, 3-bromo-4-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 3-bromo-4-hydroxy-(96245-97-5)
• EPA Substance Registry System: 2(1H)-Pyridinone, 3-bromo-4-hydroxy-(96245-97-5)

Safety Data

• Hazardous Substances Data: 96245-97-5(Hazardous Substances Data)

Usage

General Description

3-bromo-4-hydroxy-2(1H)-pyridinone is a chemical compound with the molecular formula C5H4BrNO2. It is a heterocyclic compound that contains a pyridinone ring substituted with a bromine atom at position 3 and a hydroxyl group at position 4. 2(1H)-Pyridinone, 3-bromo-4-hydroxy- is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential biological and pharmacological activities, including its ability to chelate metal ions and its potential as an antioxidant. Additionally, 3-bromo-4-hydroxy-2(1H)-pyridinone has been investigated for its role in corrosion inhibition and as a potential component in the development of new materials.

InChI:InChI=1/C5H4BrNO2/c6-4-3(8)1-2-7-5(4)9/h1-2H,(H2,7,8,9)

Upstream product

• 626-03-9 4-hydroxy-2-pyridone 
• 80791-78-2 3,5-dibromo-2,4-dihydroxypyridine 
• 626-03-9 3-deazauracil 

Downstream Products

• 184416-83-9 4-amino-2,3-dichloropyridine 
• 861023-90-7 2,3-dibromopyridin-4-amine 
• 188577-69-7 2-amino-3,4-dichloropyridine 
• 55934-02-6 2,3,4-trichloropyridine 
• 127321-90-8 3,4-dibromo-[2]pyridylamine 
• 96246-00-3 3-bromo-2,4-dimethoxypyridine 
• 586382-62-9 SC-25028 
• 1415714-29-2 1-benzyl-4-benzyloxy-3-(4-cyclohexylphenyl)pyridin-2(1H)-one 
• 1415714-28-1 1-benzyl-4-benzyloxy-3-(4-tert-butylphenyl)pyridin-2(1H)-one 
• 1310052-90-4 1-benzyl-4-benzyloxy-3-tolylpyridin-2(1H)-one 
• 1310052-86-8 1-benzyl-4-benzyloxy-3-phenylpyridin-2(1H)-one 
• 571168-92-8 1-benzyl-4-benzyloxy-3-iodopyridin-2(1H)-one 
• 1415714-27-0 1-benzyl-4-benzyloxy-3-(4-methylsulfonylphenyl)pyridin-2(1H)-on 
• 1310052-88-0 1-benzyl-4-benzyloxy-3-(3,4-methylenedioxyphenyl)pyridin-2(1H)-one 

Relevant articles and documents

Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities

A collective synthesis of 4-hydroxy-2-pyridone alkaloids - specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C - has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki-Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μM. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.

Total synthesis of (±)-cordypyridones A and B and related epimers

"Chemical Equation Presented" Efficient racemic synthesis of two antibacterial and antimalarial natural products, cordypyridones A and B, was achieved from inexpensive, commercially available starting materials In an overall yield of 15% (8% and 7%, respe