97760-75-3

Basic information

• Product Name: Acetamide, N-[4-acetyl-2-(trifluoromethyl)phenyl]-
• CAS NO: 97760-75-3
• Molecular Formula: C11H10F3NO2
• Molecular Weight: 245.201
• Mol File: 97760-75-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-acetyl-2-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-acetyl-2-(trifluoromethyl)phenyl]-(97760-75-3)
• EPA Substance Registry System: Acetamide, N-[4-acetyl-2-(trifluoromethyl)phenyl]-(97760-75-3)

Safety Data

• Hazardous Substances Data: 97760-75-3(Hazardous Substances Data)

Upstream product

• 175277-96-0 N-(4-cyano-2-(trifluoromethyl)phenyl)acetamide 
• 74-88-4 methyl iodide 
• 97760-97-9 4-iodo-2-(trifluoromethyl)aniline 
• 97760-98-0 N-(4-iodo-2-(trifluoromethyl)phenyl)acetamide 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 2926-29-6 Langlois reagent 

Downstream Products

• 54295-65-7 1-(4'-Amino-3'-trifluoromethyl-phenyl)-2-tert-butylamino-ethanol 
• 772281-16-0 N-[4-(2-tert-Butylamino-1-hydroxy-ethyl)-2-trifluoromethyl-phenyl]-acetamide 

Relevant articles and documents

Visible-light-induced Pd-catalyzed: Ortho -trifluoromethylation of acetanilides with CF3SO2Na under ambient conditions in the absence of an external photocatalyst

A visible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na was developed. The reaction proceeded smoothly at room temperature in air without any external photocatalyst or additive, providing the desired products in moderate to good yields with good functional group tolerance and regioselectivity.

Copper-free direct C-H trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate

A copper-free direct C-H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO2CF3) as the CF3 source in the presence of tert-butyl hydroperoxide (tBuOOH, TBHP) was developed.

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.