97963-62-7Relevant articles and documents
Synthesis and antimicrobial evaluations of sulfur inserted fluoro-benzimidazoles
Dwivedi, Parmesh Kumar,Chaturvedi, Devdutt
, p. 1525 - 1529 (2021/07/02)
A new series of fluorinated sulfur inserted benzimidazole analogues Za-i were synthesized and characterized. The new compounds were screened for their antimicrobial and antioxidant potential. The synthesized compounds were obtained by multiple step synthesis, initiating from the synthesis of 5-(difluoromethoxy)-1H-benzimidazole-2-thiol X. The compounds Ya-i prepared by reacting differently substituted anilines with chloroacetylchloride and triethylamine in DMF. Finally, the compound X was reacted with different derivatives of 2-chloro-N-phenylacetamide resulting in formation of titled compounds Za-i. The synthesized compounds (Za-Zi) were characterized by spectral analysis viz.1H & 13C NMR, mass spectra, elemental analysis and IR. The in vitro antimicrobial potential against Gram-positive (S. aureus and E. faecalis) and Gram-negative bacterial (E. coli and P.aeruginosa) strains as well as fungi (A. niger and C. albicans) was recorded for the obtained compounds. Some of the compounds exhibited encouraging results (in MIC) against Gram-positive and Gram-negative bacterial strains. These studies thus suggest that the designed sulfur inserted fluoro-benzimidazoles scaffold may serve as new promising template for further amplification as antimicrobial agents.
Preparation method of 4- polyfluoro methoxy O-phenylenediamine (by machine translation)
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Paragraph 0015, (2020/01/03)
The method disclosed by the invention 4 - is characterized in that the aminophenol, and the alkali :(1) are reacted at a mole ratio of the 1:0.8-1.5, 20-40 °C compound 0.1-24h with the halogen, and, the halogen compound in the solvent to 1:1.0-3.0,20-120 °C, 0.01-20Mpa react with 1-72h. 1-72h the 4 - 1:0.8-30.0 ammonia solution ;(2)4 - or the halogen compound at a mole ratio of the compound of the 1:0.2 - 2.5 amino phenol, 30-80 °C with 0.1-24h;(3)4 - the halogen and the halogen compound in the solvent 0.1-10%, 50-200 °C, 0.01-10Mpa: 4 . (by machine translation)
A 5-difruoro methoxy-2-mercapto -1H-benzimidazole synthesis method
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Paragraph 0037; 0038, (2017/02/09)
The invention relates to a method for synthesizing 5-difluoromethoxy-2-mercapto-1H-benzimidazole. According to the method, the target product 5-difluoromethoxy-2-mercapto-1H-benzimidazole is prepared through reacting 4-difluoromethoxy-o-phenylenediamine, which serves as a main starting material, with alkali and carbon disulfide in a water solvent and controlling the process conditions of two stages, namely a condensation reaction stage and a cyclization reaction stage. In two-step reaction steps, a single reaction solvent, namely water, is adopted, and any organic solvent is not adopted. By using the method disclosed by the invention, the reaction conditions are mild, the process operations are simple and environmental-friendly, the cost is low, and the yield is high.
