Reference

Nonclassical topical treatment for glaucoma using N-substituted sulfonamides

Nonclassical topical treatment for glaucoma using N-substituted sulfonamides. Barfknecht, Charles F.; Schoenwald, Ronald D. (University of Iowa Research Foundation, USA). U.S. US 4483872 A 20 Nov 1984, 6 pp. Cont.-in-part of U.S. Ser. No. 464,061. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-18. NCL: 424321000. APPLICATION: US 83-512234 11 Jul 1983. PRIORITY: US 83-464061 4 Feb 1983. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 25, 28 Eye drop compns. for treatment of glaucoma to reduce intraocular pressure comprise a nonclassical carbonic anhydrase [9001-03-0] inhibitor R(SO2NXY)n (I) where R = (un)substituted Ph; benzothiazole, substituted 1,3,4-thiadiazole; X = H or OH; Y = H or C1-6 alkyl; n = 1 or 2. Thus, a soln. was prepd. contg. 1% 1-(N-hydroxy-N-methylsulfamido-4-chlorobenzene (I, R = 4-ClC6H4; X = OH; Y = Me; n = 1)(II) [94592-95-7] and aq. pH 7.2 phosphate buffer. The lowering of intraocular pressure was demonstrated in rabbits. II was prepd. by the reaction of N-methylhydroxylamine-HCl [4229-44-1] with 4-chlorobenzenesulfonyl chloride [98-60-2].

N-(Benzenesulfonyl)erythromycylamine derivatives

N-(Benzenesulfonyl)erythromycylamine derivatives. Kobrehel, Gabrijela; Tamburasev, Zrinka; Djokic, Slobadan (PLIVA Tvornica Farmaceutskih i Kemijskih Proizvoda, Yugoslavia). U.S. US 3983103 28 Sep 1976, 5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: C07H015-20. NCL: 536009000. PRIORITY: YU 73-151 19 Jan 1973. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Section cross-reference(s): 27, 63 Bactericidal I (R = Me, Et, halo, AcNH, MeCH2CONH) were prepd. by reacting the corresponding 4-RC6H4SO2Cl (II) with erythromycylamine (III) in an inert solvent contg. an alk. 98-58-8 and 98-60-2 are cas registry numbers of chemicals which are used as reagents here. metal salt. Thus, refluxing II (R = Br) with III in Me2CO contg. NaHCO3 for 6 hr gave I (R = Br), which had a min. inhibitory concn. of 0.9 .mu./ml against Streptococcus hemolyticus strains in vitro. .