99048-48-3

Basic information

• Product Name: 2-Propyn-1-one, 1-(4-methoxyphenyl)-3-(trimethylsilyl)-
• CAS NO: 99048-48-3
• Molecular Formula: C13H16O2Si
• Molecular Weight: 232.354
• Mol File: 99048-48-3.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 2-Propyn-1-one, 1-(4-methoxyphenyl)-3-(trimethylsilyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-one, 1-(4-methoxyphenyl)-3-(trimethylsilyl)-(99048-48-3)
• EPA Substance Registry System: 2-Propyn-1-one, 1-(4-methoxyphenyl)-3-(trimethylsilyl)-(99048-48-3)

Safety Data

• Hazardous Substances Data: 99048-48-3(Hazardous Substances Data)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 1066-54-2 trimethylsilylacetylene 
• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 52898-49-4 4,N-dimethoxy-N-methylbenzamide 
• 100-09-4 4-methoxybenzoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 159351-36-7 1-(4-methoxyphenyl)-3-(trimethylsilyl)prop-2-yn-1-ol 
• 81353-38-0 (trimethylsilylethynyl)tributyltin 
• 102987-40-6 (3-(4-methoxyphenyl)prop-1-ynyl)trimethylsilane 

Downstream Products

• 16469-68-4 1-(4-methoxyphenyl)-2-propyn-1-one 
• 801287-26-3 1-trimethylsilyl-3-(4-methoxyphenyl)penta-1,4-diyn-3-ol 
• 405064-51-9 (4,4-dibromo-3-(4-methoxyphenyl)but-3-en-1-yn-1-yl)trimethylsilane 
• 1449242-32-3 ethyl 8-(4-methoxyphenyl)-2,4-diphenyl-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 2004-63-9 ethyl 6‐(4‐methoxyphenyl)‐2‐methylnicotinate 
• 1253116-75-4 (1-benzyl-1H-1,2,3-triazol-4-yl)(4'-methoxyphenyl)methanone 
• 1028866-17-2 rac-2-(4-methoxyphenyl)-1-pyridin-2-yl-4-(trimethylsilanyl)but-3-yn-2-ol 
• 153142-42-8 2-(p-methoxybenzoylacetaldehyde)-p-nitrophenylhydrazone 
• 130248-54-3 1-methoxy-4-[4-(trimethylsilyl)-1,3-butadiyn-1-yl]benzene 

Relevant articles and documents

Metabolically stable vanillin derivatives for the treatment of hypoxia

Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

Synthesis of (: Z)-β-halo α,β-unsaturated carbonyl systems via the combination of halotrimethylsilane and tetrafluoroboric acid

A convenient and broadly applicable method for the hydrohalogenation of ynones is described, by the combination of halotrimethylsilanes and tetrafluoroboric acid. Practically, one equivalent of HX (Br?nsted acid) and BF3 (Lewis acid) is smoothly generated, which activates the carbonyl compounds. Through this protocol, 42 examples of (Z)-β-halovinyl carbonyl compounds (Cl, Br and I) were obtained, in good yields and high stereoselectivity having 2-MeTHF as a solvent.

Cascade and Effective Syntheses of Functionalized Tellurophenes

A one-pot and transition-metal-catalyst-free synthetic strategy to construct functionalized tellurophenes has been developed. Substituted 1,1-dibromo-1-en-3-ynes are smoothly converted to tellurophenes with telluride salts in high yield via a series of cascade reactions through reductive debromination, hydrotelluration, nucleophilic cyclization, and aromatization. Close inspection of the results clearly showed that the reactivity of in situ prepared telluride salts are significantly influenced by the polarity of the solvent system and the electronic nature of the substituent on the enyne substrate. This method reports the first direct synthesis of 3-aryltellurophenes in high yields at room temperature. This novel reaction strategy is also found to be a promising synthetic method for multisubstituted tellurophenes and selenophenes.