2004-63-9

Basic information

• Product Name: ETHYL 6-(4-METHOXYPHENYL)-2-METHYLPYRIDINE-3-CARBOXYLATE
• Synonyms: ETHYL 6-(4-METHOXYPHENYL)-2-METHYLPYRIDINE-3-CARBOXYLATE
• CAS NO: 2004-63-9
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.31
• Mol File: 2004-63-9.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 6-(4-METHOXYPHENYL)-2-METHYLPYRIDINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 6-(4-METHOXYPHENYL)-2-METHYLPYRIDINE-3-CARBOXYLATE(2004-63-9)
• EPA Substance Registry System: ETHYL 6-(4-METHOXYPHENYL)-2-METHYLPYRIDINE-3-CARBOXYLATE(2004-63-9)

Safety Data

• Hazardous Substances Data: 2004-63-9(Hazardous Substances Data)

Upstream product

• 18096-70-3 3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 141-97-9 ethyl acetoacetate 
• 51080-14-9 1-(6-(4-methoxyphenyl)-2-methylpyridin-3-yl)ethan-1-one 
• 99048-48-3 1‐(4‐methoxyphenyl)‐3‐(trimethylsilyl)prop‐2‐yn‐1‐one 
• 626-34-6 ethyl aminocrotonate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 1609547-62-7 C₁₆H₁₈O₄ 
• 1224695-45-7 (2Z,4E)-2-amino-3-ethoxycarbonyl-6-(4-methoxyphenyl)hexadien-6-one 
• 16469-68-4 1-(4-methoxyphenyl)-2-propyn-1-one 
• 19115-30-1 1-(4-methoxyphenyl)-2-propyn-1-ol 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 18096-70-3 3-dimethylamino-4'-methoxyacrylophenone 

Relevant articles and documents

Synthesis, in vitro biological evaluation and in silico studies of certain arylnicotinic acids conjugated with aryl (thio)semicarbazides as a novel class of anti-leishmanial agents

Herein we introduce new compounds as conjugates of arylnicotinic acids with aryl (thio)semicarbazide derivatives. Based on a structure-guided approach, they were designed to possess anti-leishmanial activity through anti-folate mechanism, via targeting Le

Consecutive three- and four-component coupling-Bagley-Bohlmann-Rahtz syntheses of tri- and tetrasubstituted pyridines

The concatenation of the modified Sonogashira alkynone synthesis and the Bagley-Bohlmann-Rahtz pyridine synthesis gives novel consecutive three- and four-component coupling-Bagley-Bohlmann-Rahtz (cBBR) syntheses of tri- and tetrasubstituted pyridines in a one-pot fashion. With these processes 15 differently substituted 3-ethoxycarbonyl 2-methylpyridines can be readily obtained in modest to moderate yields.

Design, synthesis and antitubercular activity of certain nicotinic acid hydrazides

Three series of 6-Aryl-2-methylnicotinohydrazides 4a-i, N'-Arylidene-6-(4-bromophenyl)-2-methylnicotino hydrazides 7a-f, and N'-(un/substituted 2-oxoindolin-3-ylidene)-6-(4-fluorophenyl)-2-methylnicotinohydrazides 8a-c were synthesized and evaluated for their potential in vitro antimycobacterial activity against M.Tuberculosis. The results showed that isatin hydrazides 8a-c are remarkably more active than the parent hydrazide 4c. Hydrazides 8b and 8c exhibited the highest activity among all the tested compounds (MIC = 12.5 and 6.25 μg/mL, respectively). Compounds 8b and 8c were also devoid of apparent cytotoxicity to HT-29, PC-3, A549, HepG2 and MCF-7 cancer cell lines. Besides, 8b and 8c showed good drug-likeness scores of 0.62 and 0.41, respectively. Those two isatin hydrazides could offer an excellent framework for future development to obtain more potent antitubercular agents. The SAR study suggested that lipophilicity of the synthesized derivatives is a crucial element that accounts for their antimycobacterial activity. Finally, a theoretical kinetic study was established to predict the ADME of the active derivatives.