99371-94-5Relevant articles and documents
Synthesis of deuterium labeled 17-methyl-testosterone
Shinohara, Y.,Baba, S.,Kasuya, Y.
, p. 253 - 260 (1984)
The synthesis of two forms of selectively deuterated 17-methyl-testosterone is described. 17-Methyl-d3-testosterone was prepared by the Grignard reaction of dehydroepiandrosterone with deuterium labeled methyl magnesium iodide followed by an Oppenauer oxidation. 17-Methyl-d3-testosterone-19,19,19-d3 was prepared by treating 3,3-ethylenedioxy-5,10-epoxy-5α,10α-estran-17-one with deuterium labeled methyl magnesium bromide followed by hydrolysis and dehydration of the 5α-hydroxyandrostane derivative.