99848-43-8

Basic information

• Product Name: 2-Bromo-5-methoxybenzamide, 98
• Synonyms: 2-Bromo-5-methoxybenzamide, 98
• CAS NO: 99848-43-8
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.06
• Mol File: 99848-43-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 159-161℃
• Appearance: /
• CAS DataBase Reference: 2-Bromo-5-methoxybenzamide, 98(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-methoxybenzamide, 98(99848-43-8)
• EPA Substance Registry System: 2-Bromo-5-methoxybenzamide, 98(99848-43-8)

Safety Data

• Hazardous Substances Data: 99848-43-8(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-methoxybenzamide, 98 is a chemical compound that is used in various chemical and pharmaceutical applications. It is a derivative of benzamide and contains a bromine atom and a methoxy group on the benzene ring. 2-Bromo-5-methoxybenzamide, 98 is known for its high purity level of 98% and is often used as a reagent in organic synthesis and medicinal chemistry research. Its molecular structure and properties make it suitable for diverse chemical reactions and as a building block in the development of new pharmaceuticals and other specialty chemicals.

Upstream product

• 5813-86-5 m-methoxybenzamide 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 56658-04-9 2-bromo-5-methoxybenzoyl chloride 

Downstream Products

• 131002-08-9 2-ethenyl-5-methoxybenzamide 
• 887581-09-1 (2-bromo-5-methoxyphenyl)methanamine 
• 1151-70-8 6-methoxy-2-phenyl-quinazolinone-4(3H)-one 
• 1157-63-7 6-methoxy-2-(4-methoxyphenyl)-quinazolin-4(3H)-one 
• 63874-34-0 2-ethoxy-5-methoxybenzamide 
• 1269219-58-0 6-methoxy-2-(4-methylphenyl)-quinazolin-4(3H)-one 
• 62265-91-2 7-methoxy-3-phenylisoquinolin-1(2H)-one 
• 1425605-60-2 5-methoxy-2-(pentadec-1-yn-1-yl)benzamide 
• 1425605-92-0 7-methoxy-3-phenylisoquinolin-1-amine 
• 1338797-89-9 5-methoxy-2-(phenylethynyl)benzamide 
• 138642-47-4 2-bromo-5-methoxybenzonitrile 
• 1170783-74-0 (2-bromo-5-methoxyphenyl)methanaminium chloride 
• 1207252-48-9 2-(hex-1-ynyl)-5-methoxybenzamide 
• 1255775-74-6 2-(5-hydroxypent-1-ynyl)-5-methoxybenzamide 

Relevant articles and documents

Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold

The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small molecular compound development. In this work, a series of SARS-CoV-2 main protease (Mpro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 Mpro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 Mpro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.

Method for synthesizing chlorantraniliprole derivative intermediate

The invention provides a method for synthesizing a chlorantraniliprole derivative intermediate, belonging to the field of agricultural pesticides. The method comprises the following steps: subjectingthe intermediate 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid to chlorination so as to prepare 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-formyl chloride; subjecting the raw material 2-bromobenzoic acid to acylating chlorination and ammoniation so as to prepare substituted 2-bromo-benzamide; and subjecting 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-formyl chloride and substituted 2-bromo-benzamide to cyclization so as to obtain the chlorantraniliprole derivative intermediate. The method of the invention is simple and common; reagents used in the process of synthesis are low in toxicity, used solvents are recyclable, and few by-products are produced, so the method has little corrosion to equipment and low pollution to environment; since raw materials are cheap, production cost is reduced and good economical efficiency is obtained; therefore, the method has good application prospects.

Certain pyrazoline derivatives with kinase inhibitory activity

The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.