56658-04-9

Basic information

• Product Name: 2-BROMO-5-METHOXYBENZOYL CHLORIDE
• Synonyms: 2-BROMO-5-METHOXYBENZOYL CHLORIDE;2-BROMO-5-METHOXYBENZENE-1-CARBONYL CHLORIDE;BUTTPARK 43\57-16;6-Bromo-m-anisoyl chloride
• CAS NO: 56658-04-9
• Molecular Formula: C₈H₆BrClO₂
• Molecular Weight: 249.49
• Mol File: 56658-04-9.mol
• Article Data: 51

Chemical Properties

• Boiling Point: 110 °C
• Flash Point: 175-177°C/15mm
• Appearance: /
• Density: 1.598 g/cm³
• Vapor Pressure: 0.00121mmHg at 25°C
• Refractive Index: 1.565
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-BROMO-5-METHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-METHOXYBENZOYL CHLORIDE(56658-04-9)
• EPA Substance Registry System: 2-BROMO-5-METHOXYBENZOYL CHLORIDE(56658-04-9)

Safety Data

• Hazard Codes: Xn
• Statements: 34-22
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 56658-04-9(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-methoxybenzoyl chloride is a chemical compound with the formula C8H6BrClO2. It is a benzoyl chloride derivative with a bromine atom at the 2-position and a methoxy group at the 5-position of the benzene ring. 2-BROMO-5-METHOXYBENZOYL CHLORIDE is commonly used in organic synthesis as a versatile building block for the introduction of the benzoyl and methoxy functional groups into various organic molecules. It is often used in the production of pharmaceuticals, agrochemicals, and other fine chemicals due to its reactivity and ability to selectively modify specific positions on aromatic rings. Additionally, it can also be used in the synthesis of dyes and other aromatic compounds.

InChI:InChI=1/C8H6BrClO2/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4H,1H3

Upstream product

• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 586-38-9 3-Methoxybenzoic acid 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 944836-37-7 (S)-2-(2-bromo-5-methoxyphenyl)-4-(tert-butyl)-4,5-dihydrooxazole 
• 108059-70-7 2-(2-Acetyl-4-methoxyphenylthio)benzoesaeure 
• 108081-63-6 2-(2-Acetyl-4-methoxyphenylthio)benzoesaeure-methylester 
• 1375931-12-6 2-bromo-N,N-diisopropyl-5-methoxylbenzamide 
• 1061911-25-8 C₁₆H₁₄BrNO₄ 
• 1381842-10-9 C₁₈H₁₆BrNO₆ 

Relevant articles and documents

Multistep Synthesis and Nematicidal Activity of 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-One Derivatives

[Figure not available: see fulltext.] Novel 2-(8-azabicyclo[3.2.1]octan-3-yl)-3-imino-2,3-dihydro-1H-isoindol-1-ones derived from 5-HT3 receptor antagonists hexahydroazepinylbenzamides were designed and synthesized through isocyanide insertion reaction. All target compounds were evaluated against pinewood nematodes B. xylophilus and root-knot nematodes M. incognita. Good lethal rate (75%) for 3-(tert-butylimino)-5-chloro-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dihydro-1H-isoindol-1-one and serious nervous curl effect against pinewood nematodes B. xylophilus for 3-(tert-butylimino)-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dihydro-1H-isoindol-1-one were observed at 10 mg/l. The inhibition activities of 3-[(4-methoxyphenyl)imino]-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dihydro-1H-isoindol-1-one against root-knot nematodes M. incognita were 84% at 160 mg/l and 60% at 20 mg/l for in vitro test and test tube test, respectively.

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1) removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can potentiate the cytotoxicity of TOP1 inhibitors and overcome cancer cell resistance to

Direct Synthesis of Enamides via Electrophilic Activation of Amides

A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.