intedanib basic information |
product name: | intedanib |
synonyms: | intedanib;vargatef;nintedanib;nintedanib (bibf 1120);nintedanib/intedanib/vargatef;intedanib vargatef;methyl (3z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1h-indole-6-carboxylate nintedanib (bibf 1120);vargatef (nintedanib) |
cas: | 656247-17-5 |
mf: | c31h33n5o4 |
mw: | 539.62482 |
einecs: | |
product categories: | amines;heterocycles;intermediates & fine chemicals;pharmaceuticals;inhibitors |
mol file: | 656247-17-5.mol |
intedanib chemical properties |
safety information |
intedanib usage and synthesis |
usage | it is an indolinone derivative potently blocking vegf-, pdgf-, and fgf-receptor kinases; an indolinone as triple angiokinase inhibitors. |
usage | bibf1120 (vargatef) is a potent inhibitor of vegfr1/2/3, fgfr1/2/3 and pdgfrα/β with ic50 of 34 nm/13 nm/13 nm, 69 nm/37 nm/108 nm and 59 nm/65 nm, respectively |
intedanib basic information |
product name: | intedanib |
synonyms: | intedanib;vargatef;nintedanib;nintedanib (bibf 1120);nintedanib/intedanib/vargatef;intedanib vargatef;methyl (3z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1h-indole-6-carboxylate nintedanib (bibf 1120);vargatef (nintedanib) |
cas: | 656247-17-5 |
mf: | c31h33n5o4 |
mw: | 539.62482 |
einecs: | |
product categories: | amines;heterocycles;intermediates & fine chemicals;pharmaceuticals;inhibitors |
mol file: | 656247-17-5.mol |
intedanib chemical properties |
safety information |
intedanib usage and synthesis |
usage | it is an indolinone derivative potently blocking vegf-, pdgf-, and fgf-receptor kinases; an indolinone as triple angiokinase inhibitors. |
usage | bibf1120 (vargatef) is a potent inhibitor of vegfr1/2/3, fgfr1/2/3 and pdgfrα/β with ic50 of 34 nm/13 nm/13 nm, 69 nm/37 nm/108 nm and 59 nm/65 nm, respectively |