chemical properties fluffy solid. [α] d23-31.7 ° (c = 1, 1% acetic acid).
(ghrh) and follicle stimulating hormone (fsh), regulate the secretion of gonadotropin, improve the serum concentration of testosterone and dihydrotestosterone, and increase the serum concentration of testosterone and dihydrotestosterone, so as to achieve the function of the treatment of reproductive system diseases. for the treatment of prostate cancer, uterine fibroids, ovarian cysts, breast cancer and children with cryptorchidism and so on.
use of peptide raw materials
production method phenol and phosgene reaction, the formation of phenyl chloroformate, and tert-butanol reaction, the formation of tert-butoxyphenyl phenyl ester, followed by hydrazine reaction, and then nitrosation to produce tert-butyl azide, and then bright ammonia acid reaction to obtain leucine side chain.
the proline side chain can also be obtained.
the serine is reacted with benzyl chloride to protect the hydroxyl group and react with t-butyl azide to give the serine side chain.
similar to serine, side chains of tyrosine and histidine can be obtained.
tert-butyl azide and tryptophan, and then reacted with 2,4,6-trimethoxybenzenesulfonyl chloride to give the tryptophan side chain.
tert-butyl azanoate and arginine, and then p-toluenesulfonyl chloride reaction, to obtain arginine side chain.
after the above-mentioned side chain is obtained, the peptide is further reacted with ethylamine, followed by reaction with ethylamine, and then deprotecting or hydrogenolysis to remove the support base.