Reference

1-Octanol-water partition coefficients of the anionic and zwitterionic species of diprotic zwitterionic cephalosporin antibiotics

1-Octanol-water partition coefficients of the anionic and zwitterionic species of diprotic zwitterionic cephalosporin antibiotics. Irwin, Vincent P.; Quigley, John M.; Timoney, Richard F. (Sch. Pharm., Trinity Coll., Dublin, Ire.). Int. J. Pharm., 43(1-2), 187-8 (English) 1988. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The octanol-water partition coeffs. of 3 diprotic zwitterionic cephalosporin, cephalexin, cephaloglycin, and cephradine, at 37° and ionic strength 0.2M were detd. It is possible, using graphical-regression techniques, to apply the equation, P (1 + aH+/Ka2) = Pan + Pzw = (aH+/Ka2) to the exptl. P data of each compd. at pH >5 to det. the true partition coeffs. of the anionic and zwitterionic species, Pan and Pzw, resp. The relation may be applied to the P data for any diprotic zwitterionic compd. which undergoes anionic partitioning and which has a difference between pKa1and pKa2 values of sufficient magnitude.

Excess enthalpy

Excess enthalpy. 1-Octanol (n-octyl alcohol)-n-heptane system. Van Ness, H. C.; Abbott, M. M. (Dep. Chem. Environ. Eng., Rensselaer Polytech. Inst., Troy, N. Y., USA). Int. Data Ser., Sel. Data Mixtures, Ser. A, (1), 18 (English) 1976. CODEN: ISDMAT. DOCUMENT TYPE: Journal CA Section: 69 (Thermodynamics, Thermochemistry, and Thermal Properties) A data table.