MK-0752 CAS NO.471905-41-6

Min.Order Quantity:: 1 Kilogram

Purity:: 98%

Port:: tianjin or Qingdao

Payment Terms:: L/C,T/T

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MK-0752
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Quick Details

ProName: MK-0752
CasNo: 471905-41-6
Molecular Formula: C21H21ClF2O4S
Appearance: powder
Application: used in pharmaceutical intermediate
DeliveryTime: 3 days after receive your advanced pay...
PackAge: as client's required
Port: tianjin or Qingdao
ProductionCapacity: 10 Metric Ton/Month
Purity: 98%
Storage: Store in dry, dark and ventilated pla...
Transportation: as client's required
LimitNum: 1 Kilogram
package: as requested
delivery time: 3-7 days
port: as required
package: as required
LimitNum: 1 Gram
Brand: Luspharm

Superiority

our strength

we have clients throughout the world：

professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.

our laboratoy

we have our own independent lab test center：

this makes sure that our technology support is reliable and authoritative.all of self-owned fine chemicals are manufactured strictly in accordance with international standard.,and also has scientific cooperation with local colleges and institutes.

our factory

high quality with competitive price：

we are manufacturer and can provide high quality products with factory price.

package & shipment

fast and safe delivery：

parcels can be sent out within 24 hours after payment.

tracking number is available secure and discreet shipment.

you have various choices of transportation methods.

Details

product information:

mk-0752 basic information

product name:	mk-0752
synonyms:	cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid;cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-;mk-0752/mk0752;3-(cis-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid mk-0752;mk-0752, >=98%
cas:	471905-41-6
mf:	c21h21clf2o4s
mw:	443
einecs:
product categories:	inhibitor;inhibitors
mol file:	471905-41-6.mol

mk-0752 chemical properties

density

1.361

safety information

msds information

mk-0752 usage and synthesis

usage

γ-secretase is a protease complex that cleaves single-pass transmembrane proteins, such as notch receptors and β-amyloid precursor protein (app), within the transmembrane domain. mk-0752 is a potent, reversible inhibitor of γ-secretase, reducing the cleavage of app to aβ40 in human neuroblastoma sh-sy5y cells with an ic50 value of 5 nm. it is orally bioavailable and crosses the blood-brain barrier, as orally administered mk-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys. through its effects on the notch pathway, mk-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel in mice with breast cancer tumors.[cayman chemical]

company information:

hebei luspharm trading co., ltd. is a high-tech enterprise engages in manufacturing and marketing chemicals for international distribution,specialized in apis, advanced intermediates, botanical extract and color industry.

our goal is becoming leading position in global distribution and trading based on unique combination of technical skill,unrivaled supplier network, market knowledge and an absolute commitment to customer satisfaction.

under a management team with professional experiences in chemical development, a pathbreaking optimization in our r&d center,advanced multi-purpose manufacturing facility and large-scale production line with gmp workshop, we can supply finished synthesis as client requirements and be sure high quality products,low costs, adequate supply and integrated excellent services.

luspharm headquarters are located in shijiazhuang, china. hebei luspharm trading co., ltd. is in charge of all business of luspharm.

our mission and enthusiasm is introducing the high quality chinese ingredients to global customers, and becoming a bridge between the changing china and the changing needs of our clients.focus, then the best".

adhering to the tenet of "today's quality will open up tomorrow's market", insisting on the philosophy of "integrity, win-win", we would like to cooperate with friends at home and abroad for creating bright future.