Dose-dependent effects of Mosapride citrate (cas 112885-42-4) on duodenal and cecal motility in donkeys (Equus asinus)

Add time:07/29/2019    Source:sciencedirect.com

Prokinetic drugs are used for the management of gastrointestinal motility disorders in horses; however, little is known about their efficacy in donkeys. Therefore, the aim of the present study was to evaluate the effect of different doses of Mosapride citrate (cas 112885-42-4) on duodenal and cecal motility in normal donkeys. Six donkeys (n = 6) were used in a crossover study. Mosapride citrate was administered orally via a nasogastric tube at dose rate of 1, 2 and 3 mg kg−1. Duodenal and cecal motility were evaluated using ultrasonography before administration and at 15, 30, 60, 120 and 180 min post-administration. There was a significant increase of duodenal contractions (p < 0.05) after 30 min of mosapride citrate administration at 3 mg kg−1 with a prolonged (p < 0.05) prokinetic effect at 2 mg kg−1. Cecal contractions were significantly increased (p < 0.05) after 15 min at different doses of mosapride with a prolonged effect at 3 mg kg−1. The results of the present study indicate that mosapride citrate has a dose-dependent prokinetic effect on the duodenal and cecal contractions in healthy donkeys. Further studies need to determine whether mosapride citrate is effective in treatment of intestinal disorders in donkey.

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