Association of high 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients
-
Add time:09/28/2019 Source:sciencedirect.com
Here, we determined the 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial salivary glands (LSG) from Sjögren's syndrome (SS)-patients and the effect of cytokines on HSG cells. LSG from SS-patients, controls and HSG cells incubated with cytokines were analysed. Levels of 5mC, 5hmC, DNMTs, TET2 and MeCP2 were assessed by immunofluorescence. In epithelial cells from SS-patients, an increase in TET2, 5hmC and a decrease in 5mC and MeCP2 were observed, additionally, high levels of 5mC and DNMTs and low levels of 5hmC were detected in inflammatory cells. Cytokines increased TET2 and 5hmC and decreased 5mC levels. Considering that the TET2 gene.promoter contains response elements for transcription factors activated by cytokines, together to in vitro results suggest that changes in DNA hydroxymethylation, resulting from altered levels of TET2 are likely to be relevant in the Sjögren's syndrome etiopathogenesis.
We also recommend Trading Suppliers and Manufacturers of 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1). Pls Click Website Link as below: cas 1123-95-1 suppliers
Prev:Contributions to Progress and Promise of Epigenetics for Diagnosis and Therapy in Cancer5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) in cancer: significance in diagnosis and therapy
Next:5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1): A stable or transient DNA modification?) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Research Report5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) is detected in RNA from mouse brain tissues09/30/2019
- 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1): A stable or transient DNA modification?09/29/2019
- Contributions to Progress and Promise of Epigenetics for Diagnosis and Therapy in Cancer5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) in cancer: significance in diagnosis and therapy10/01/2019
- The role of 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) in development, aging and age-related diseases09/27/2019
- A convenient electrogenerated chemiluminescence biosensing method for selective detection of 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) in genomic DNA09/26/2019
- Hypersensitive quantification of global 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1) by chemoenzymatic tagging09/25/2019
- Review ArticleOxidized C5-methyl cytosine bases in DNA: 5-HYDROXYMETHYLCYTOSINE (cas 1123-95-1); 5-formylcytosine; and 5-carboxycytosine☆09/24/2019