Aloin (cas 1415-73-2) attenuates cognitive impairment and inflammation induced by d-galactose via down-regulating ERK, p38 and NF-κB signaling pathway

Add time:10/01/2019    Source:sciencedirect.com

Oxidative stress is considered as major culprit for neurodegenerative diseases and triggers cognitive and memory impairments. The present study mainly aimed to study the protective effects and underlying mechanisms of Aloin (cas 1415-73-2) on d-galactose (d-gal) induced ageing mice. Our results demonstrated that chronic administration of d-gal (150 mg kg−1) in mice caused spontaneous and cognitive impairments, as determined by open-field test and Morris water-maze test. Aloin treatment significantly ameliorated histopathological damage, attenuated the microglia activation and reduced levels of inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6 in the hippocampus. Moreover, it effectively suppressed the level of reactive oxygen species (ROS) and increased antioxidant enzymes activities. Further data showed that these protective effects were accompanied by inhibition of the activation of nuclear factor kappa B and the phosphorylation of p38 and ERK. In conclusion, the present study suggests that aloin can ameliorate d-gal induced oxidative stress, cognitive impairment and inflammation, possibly via mediating the ERK, p38 and NF-κB signaling pathways.

We also recommend Trading Suppliers and Manufacturers of Aloin (cas 1415-73-2). Pls Click Website Link as below: cas 1415-73-2 suppliers

Prev:Evaluation of efficacy of Aloin (cas 1415-73-2) in treating acute trauma in vitro and in vivo
Next:Full length articleRole of Aloin (cas 1415-73-2) in the modulation of certain immune parameters in skin mucus of an Indian major carp, Labeo rohita)