A MILD AND FACILE SYNTHESIS OF CARBOXYLIC ANHYDRIDES
Reaction of carboxylic acids with trimethylsilylethoxyacetylene in an inert solvent under mild conditions affords the corresponding carboxylic anhydrides in almost quantitative yields.
Kita, Y.,Akai, S.,Yoshigi, M.,Nakajima, Y.,Yasuda, H.,Tamura, Y.
Linear, Mannitol-Based Poly(anhydride-esters) with High Ibuprofen Loading and Anti-Inflammatory Activity
Sugar alcohols, such as mannitol and xylitol, are biocompatible polyols that have been used to make highly cross-linked polyester elastomers and dendrimers for tissue engineering and drug delivery. However, research that utilizes the secondary hydroxyl gr
Stebbins, Nicholas D.,Yu, Weiling,Uhrich, Kathryn E.
Accessing 4-oxy-substituted isoquinolinones via C-H activation and regioselective migratory insertion with electronically biased ynol ethers
The rhodium-catalyzed C-H activation and annulation with ynol ethers to directly provide 4-oxy substituted isoquinolinones is reported. The polarized nature of ynol ethers provides an electronic bias for controlling the regioselectivity of the migratory insertion process. While the highly reactive nature of ynol ethers presents a challenge, mild conditions were found to provide product in moderate to good yield. Utility was demonstrated by application in the synthesis of a prolyl-4-hydroxylase inhibitor framework.
Coles-Taylor, Brandon L.,McCallum, Maximilian S.,Michel, Brian W.,Lee, J. Scott
supporting information
p. 8639 - 8646
(2018/12/01)
Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions
The previously unexplored metal-catalyzed [5 + 2] cycloadditions of vinylcyclopropanes (VCPs) and electron-rich alkynes (ynol ethers) have been found to provide a highly efficient, direct route to dioxygenated seven-membered rings, a common feature of num
Wender, Paul A.,Ebner, Christian,Fennell, Brandon D.,Inagaki, Fuyuhiko,Schr?der, Birte
supporting information
p. 5810 - 5813
(2017/11/10)
Generation and Trapping of Cyclopropenes from 2-Alkoxy-1,1-dichlorocyclopropanes
In presence of crown ether, 2-alkoxy-1,1-dichlorocyclopropanes react with t-BuOK/THF preferentially via ring opening to 2-chloroalk-2-en-1-ones and alkynones or to chlorocyclopropenes.The latter may be intercepted with 1,3-diphenylisobenzofuran, but in th
Mueller, Paul,Pautex, Nicole
p. 55 - 64
(2007/10/02)
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