- Synthesis of substituted pyridine derivatives via the ruthenium-catalyzed cycloisomerization of 3-azadienynes
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We describe a two-step conversion of various N-vinyl and N-aryl amides to the corresponding substituted pyridines and quinolines, respectively. The process involves the direct conversion of amides, including sensitive N-vinyl amides, to the corresponding trimethylsilyl alkynyl imines followed by a ruthenium-catalyzed protodesilylation and cycloisomerization. A wide range of new alkynyl imines are prepared and readily converted to the corresponding azaheterocycles. Copyright
- Movassaghi, Mohammad,Hill, Matthew D.
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- Ecofriendly synthesis of thieno[2,3-b]pyridines derivativies
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In order to avoid the use of too much organic solvent and harmful catalysts, 2-aminothiophenes are readily transformed to thienopyridines by an ecofriendly synthesis in a suitable solvent system. This reaction in aqueous medium and under microwave irradiation takes lesser time and results in higher yield as compared to conventional method.
- Kidwai,Priya,Poddar
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experimental part
p. 270 - 273
(2010/11/02)
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- Synthesis of substituted pyridines and quinolines
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A variety of N-vinyl and N-aryl amides were converted to the corresponding pyridine and quinoline derivatives, respectively. Amide activation and nucleophilic addition of copper(I) (trimethylsilyl)acetylide efficiently provided the desired alkynyl imines. Ruthenium-catalyzed protodesilylation and cycloisomerization of these imines gave the corresponding azaheterocycles. Georg Thieme Verlag Stuttgart.
- Hill, Matthew D.,Movassaghi, Mohammad
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p. 1115 - 1119
(2008/02/02)
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- Intramolecular Diels-Alder Reactions of 1,2,4-Triazines. A Facile Synthesis of Thienopyridines and 3,4-Dihydro-2H-thiopyranopyridines
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Thienepyridines and 3,4-dihydro-2H-thiopyranopyridines have been prepared in high overall yields via intramolecular Diels-Alder reactions of properly substituted 1,2,4-triazine derivatives.A one-pot synthesis of 2,3-dihydrothienopyrid
- Taylor, Edward C.,Macor, John E.
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p. 4280 - 4287
(2007/10/02)
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- NOVEL INTRAMOLECULAR DIELS-ALDER REACTIONS WITH ALKYNYLTHIO DERIVATIVES OF 1,2,4-TRIAZINES. NEW ROUTES TO THIENOPYRIDINES AND THIENOPYRIDINES
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S-Alkylation of 1,2,4-triazine-6-thiones with 4-iodobutyne, followed by oxidation to the sulfoxide and intramolecular cycloaddition (at room temperature), gives 2,3-dihydrothienopyridines, which are readily dehydrated with acetic anhydride to thien
- Taylor, Edward C.,Macor, John E.
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p. 2419 - 2422
(2007/10/02)
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