- Novel Phosphinic Acid-Containing Thyromimetics
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The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.
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Page/Page column 144
(2009/02/11)
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- A novel mode of access to polyfunctional organotin compounds and their reactivity in Stille cross-coupling reaction
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Mono-, di-, tri- and tetra-functional organotin compounds were easily prepared in a sonicated Barbier reaction using ultrasound technology via coupling reaction of organo halides with tin halides (Bu3SnCl, Bu2SnCl2, BuSnCl
- Lamandé-Langle, Sandrine,Abarbri, Mohamed,Thibonnet, Jér?me,Duchêne, Alain
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p. 2368 - 2374
(2009/09/30)
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- Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
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Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.
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Page/Page column 65
(2008/12/07)
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- THERAPEUTIC AGENT FOR DIABETES
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A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.
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- A New Synthesis of Vinyltins by Reaction of Phosphorus Ylides with Acyltins
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Acyltins react with various phosphorus ylides to afford the corresponding vinyltin derivatives, an alternative methodology for the preparation of these useful reagents.This method has been applied to the synthesis of functionally substituted vinyltins.
- Verlhac, Jean-Baptiste,Kwon, HeeAn,Pereyre, Michel
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p. 1367 - 1368
(2007/10/02)
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- Synthesis of Allylstannanes and Vinylstannanes by the Stannyl-cupration of Allenes
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Stannyl-cupration of allenes followed by electrophilic attack gives allyl- and vinyl-stannanes with a variety of substitution patterns.The regiochemistry of the reaction depends upon the temperature at which the intermediate cuprate is quenched with an electrophile.With allene itself, the allylstannane-vinylcuprate 1-(tributylstannylmethyl)vinylcuprate 5, is the product of kinetically controlled addition, but the vinylstannane-allylcuprate 2-(tributylstannyl)allylcuprate 6, is thermodynamically lower in energy.The equilibrium between these isomers begins to take place between -100 and -78 deg C.
- Barbero, Asuncion,Cuadrado, Purificacion,Fleming, Ian,Gonzalez, Ana M.,Pulido, Francisco J.
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p. 327 - 332
(2007/10/02)
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- SYNTHESIS AND FLASH-PYROLYSIS OF ORGANOTIN -SUBSTITUTED CARBAMATES AND OXALATES
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Organotin -substituted alcohols react readily with aryl(alkyl) isocyanates and oxalyl chloride to give the corrresponding organotin -substituted carbamates and oxalates.Under flash pyrolytic conditions, these esters decompose into vinyltin derivatives.
- Ratier, Max,Khatmi, Djamel,Duboudin, Jean-Georges
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p. 467 - 482
(2007/10/02)
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- The Synthesis of Allylstannanes and Vinylstannanes by the Stannyl-cupration of Allenes
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Stannyl-cupration of allenes followed by electrophilic attack gives allyl- and vinylstannanes with a variety of substitution patterns; the regiochemistry of the reaction depends upon the temperature and the nature of the stannyl-cuprate reagent.
- Barbero, Asuncion,Cuadrado, Purificacion,Fleming, Ian,Gonzalez, Ana M.,Pulido, Francisco J.
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p. 1030 - 1031
(2007/10/02)
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- THERMAL DECOMPOSITION OF ORGANOTIN SULFAMATES: A ONE POT SYNTHESIS OF VINYLTRIBUTYLTIN COMPOUNDS
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The preparation of some alkyltributyltin sulfamates is described.Thermal decomposition of these compounds provides a route to vinyltributyltin derivatives.
- Ratier, Max,Khatmi, Djamel,Duboudin, J.Georges,Minh, Dao The
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p. 285 - 292
(2007/10/02)
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- Synthese et thermolyse eclair d'esters α-tributylstanniques
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The preparation of some alkyltributyltin acetates and thiocarbonates is described.Flash thermolysis of these compounds at high temperature (600-950 deg C) and under a moderate vacuum, provides a new route to vinyltributyltin derivatives.
- Duboudin, J. Georges,Ratier, Max,Trouve, Bruno
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p. 181 - 192
(2007/10/02)
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