- 4-Alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation
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A series of novel 4-alkoxy-3-arylfuran-2(5H)-ones as tyrosyl-tRNA synthetase inhibitors were synthesized. Of these compounds, 3-(4-hydroxyphenyl)- 4-(2-morpholinoethoxy)furan-2(5H)-one (27) was the most potent. The binding model and structure-activity rel
- Xiao, Zhu-Ping,Ouyang, Hui,Wang, Xu-Dong,Lv, Peng-Cheng,Huang, Ze-Jun,Yu, She-Rong,Yi, Tian-Fang,Yang, Ye-Ling,Zhu, Hai-Liang
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p. 3884 - 3891
(2011/08/02)
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- 3-Aryltetronic acids: Efficient preparation and use as precursors for vulpinic acids
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3-Aryltetronic acids were prepared in one step by treatment of a mixture of methyl arylacetates and methyl hydroxyacetates with potassium tert-butoxide, via tandem transesterification/Dieckmann condensation. Several mushroom or lichen pigments, vulpinic acids, were synthesized from 3-(4-methoxyphe-nyl) tetronic acid in three steps involving the reaction of the corresponding dianion with an α-ketoester and the dehydration of the tertiary alcohols obtained into mixtures of (E)-and (Z)-alkenes, which were converted under UV irradiation at 254 nm to natural (E)-isomers. Syntheses of pinastric acid, 4,4′-dimethoxyvulpinic acid, and the first synthesis of recently isolated methyl 3′,5′-dichloro-4,4′-di-0-methylatromentate were hence achieved in an efficient manner.
- Mallinger, Aurelie,Gall, Thierry Le,Mioskowski, Charles
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supporting information; experimental part
p. 1124 - 1129
(2009/07/11)
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- Synthesis of (E)- and (Z)-Pulvinones
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Two new routes to pulvinones have been developed, one of which involves a novel Wittig reaction.For the first time, members of the E-series, including the parent (E)-pulvinone, are reported and the structural elucidation of the geometric isomers is descri
- Campbell, Alexander C.,Maidment, Maurice S.,Pick, John H.,Stevenson, Donald F. M.
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p. 1567 - 1576
(2007/10/02)
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