Novel approach for the conversion of natural Δ3 cephalosporin derivatives into corresponding Δ2 cephalosporin derivatives
(Chemical Equation Presented) A simple one pot synthetic method for the isomerization of cephem double bond from the natural 3-position to 2-cephem positions is affected by silylation. Thus cephalosporin acids are treated with N-trimethylsilylacetamide (MSA) or N,O-bis(trimethylsilyl)acetamide (BSA) and the resulting silyl esters are treated with triethylamine at ambient temperature in the same pot to afford Δ2-cephalosporins, which are potentially related compounds in cephalosporin antibacterial compounds.
Prasada Rao, Korrapati V. V.,Dandala, Ramesh,Handa, Vijay K.,Kamat, Anand G.,Subramanyeswara Rao, Inti V.,Rani, Ananta,Naidu, Andra
p. 1513 - 1515
(2008/09/18)
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