100114-37-2Relevant articles and documents
Mild and efficient addition of carbon nucleophiles to condensed pyridines: influence of structure and limits of applicability
Starosotnikov, Alexey M.,Ilkov, Kirill V.,Bastrakov, Maxim A.,Fedyanin, Ivan V.,Kokorekin, Vladimir A.
, p. 92 - 100 (2020)
[Figure not available: see fulltext.] A number of azolo- and azinopyridines with varying substituents and annulated heterocycles were synthesized and examined in dearomatization reactions with carbon nucleophiles. Depending on the structure, the resulting covalent σ-adducts were formed either under basefree conditions or in Et3N-promoted process to give functionalized condensed dihydropyridines. Quantum-chemical calculations of the global electrophilicity index derived from FMO energies of azolopyridine series were performed to explain reactivity toward neutral and anionic C-nucleophiles. These values may be useful for qualitative prediction of particular reactivity pattern.
A method for synthesis of the imidazole derivatives (by machine translation)
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Paragraph 0023; 0024, (2017/09/29)
The invention discloses a imidazole derivatives 6 - chloro - 3 - methyl - 3 H - imidazo [4, 5 - b] pyridine - 2 - benzaldehyde preparation method, in order to 2, 5 - dichloro - 3 - nitro-pyridine as the starting material, through nucleophilic, reduction, ring, hydrolysis reaction to obtain the target product, the compound is an important medical intermediates. (by machine translation)
