21427-62-3

Basic information

• Product Name: 2,5-Dichloro-3-nitropyridine
• Synonyms: 2,5-DICHLORO-3-NITROPYRIDINE;2,5-Dichloro-3-nitropyridine ,97%
• CAS NO: 21427-62-3
• Molecular Formula: C₅H₂Cl₂N₂O₂
• Molecular Weight: 192.99
• Product Categories: Pyridine;Chlorinated heterocyclic series;Pyridines;Heterocycle-Pyridine series
• Mol File: 21427-62-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 39-45 °C
• Boiling Point: 265.292 °C at 760 mmHg
• Flash Point: >110°(230°F)
• Appearance: Light beige-green to orange/Crystalline Powder and/or Chunks
• Density: 1.63 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: -4.99±0.10(Predicted)
• CAS DataBase Reference: 2,5-Dichloro-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dichloro-3-nitropyridine(21427-62-3)
• EPA Substance Registry System: 2,5-Dichloro-3-nitropyridine(21427-62-3)

Safety Data

• Hazard Codes: Xn,Xi,T
• Statements: 36/37/38-22-43-41-37/38-25
• Safety Statements: 36/37/39-26-45
• RIDADR: 2811
• WGK Germany: 1
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 21427-62-3(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline powder

InChI:InChI=1/C5H2Cl2N2O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H

Upstream product

• 21427-61-2 5-chloro-3-nitropyridin-2(1H)-one 
• 5409-39-2 2-amino-5-chloro-3-nitropyridine 
• 4214-79-3 5-chloro-1,2-dihydropyridin-2-one 
• 75-44-5 phosgene 
• 21427-61-2 5-chloro-3-nitropyridin-2-ol 
• 4214-79-3 5-chloro-2-pyridinol 

Downstream Products

• 144728-30-3 5-Chloro-N²-(4-methylsulfanyl-benzyl)-pyridine-2,3-diamine 
• 136122-51-5 N²-(4-Bromo-2-fluoro-benzyl)-5-chloro-pyridine-2,3-diamine 
• 136122-55-9 6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]pyridine-2-thiol 
• 136122-56-0 3-(4-Bromo-2-fluoro-benzyl)-6-chloro-3H-imidazo[4,5-b]pyridine-2-thiol 
• 147643-73-0 2-[6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylsulfanyl]-2-methyl-propionic acid ethyl ester 
• 136145-12-5 ethyl 4-<3-<(4-chlorophenyl)methyl>-6-chloroimidazo<4,5-b>pyridin-2-yl>-3,3-dimethylbutanoate 
• 147643-72-9 4-[6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]pyridin-2-ylsulfanyl]-butyric acid ethyl ester 
• 147643-82-1 4-[6-Chloro-3-(4-methylsulfanyl-benzyl)-3H-imidazo[4,5-b]pyridin-2-yl]-3,3-dimethyl-butyric acid ethyl ester 
• 136122-59-3 4-[3-(4-Bromo-2-fluoro-benzyl)-6-chloro-3H-imidazo[4,5-b]pyridin-2-ylsulfanyl]-butyric acid ethyl ester 
• 181123-11-5 5-chloro-2-cyano-3-nitropyridine 
• 943636-90-6 C₂₁H₂₅ClN₄O₅ 
• 433728-66-6 2-(6-chloro-3-nitropyridin-2-yl)-N,N-diisopropylbenzamide 
• 1400702-24-0 4-chloro-1-methyl-N-[4-(trifluoromethoxy)benzyl]-1H-pyrrolo [2,3-c]pyridine-7-amine 
• 1400698-59-0 ethyl 4-({(4-chloro-1-methyl-1H-pyrrolo[2,3-c]pyridin-7-yl)[4-(trifluoromethoxy)benzyl]amino}sulfonyl)benzoate 

Relevant articles and documents

NOVEL STING AGONISTS

The present invention provides compounds of Formula I′: wherein , W, X, Y, Z, Z1, Z2, R1, R2, R3, R4 and R5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the STING protein and thus can be used as medicaments for treating or preventing disorders affected by the agonism of STING.

PYRAZOLONE DERIVATIVE HAVING CYCLIC SIDE CHAIN

PROBLEM TO BE SOLVED: To provide a compound that has excellent inhibitory action on ATPase activity of TIP48/TIP49 complex and is therefore useful for the treatment of tumor, or a pharmacologically acceptable salt thereof. SOLUTION: The present invention provides a compound having a structure represented by general formula (I), its pharmacologically acceptable salt, or a pharmaceutical composition comprising the compound (where R1, R2, R3, R4, R5, R6, R7, W, and Z are as defined in the specifications). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors

New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.