100123-25-9

Basic information

• Product Name: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE
• Synonyms: 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE
• CAS NO: 100123-25-9
• Molecular Formula: C₁₂H₁₀BrNO₃
• Molecular Weight: 296.12
• Mol File: 100123-25-9.mol

Chemical Properties

• Melting Point: 245 °C(Solv: ethanol (64-17-5))
• Boiling Point: 476.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.608±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.56±0.30(Predicted)
• CAS DataBase Reference: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE(100123-25-9)
• EPA Substance Registry System: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE(100123-25-9)

Safety Data

• Hazardous Substances Data: 100123-25-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE is used as a synthetic building block for the development of novel pharmaceutical compounds. Its unique structure allows for the creation of new molecules with potential therapeutic properties, contributing to the advancement of drug discovery and development.
Used in Chemical Research:
In the field of chemical research, ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE is used as a reactant in various synthetic reactions. Its reactivity and structural features make it a valuable tool for exploring new synthetic pathways and developing innovative chemical processes.
Used in the Synthesis of Hydroxyindolecarboxylates:
ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE is used as a reactant in the synthetic preparation of hydroxyindolecarboxylates through Baeyer-Villiger oxidation. This reaction is an important method for converting ketones into esters, and the use of this compound as a starting material can lead to the development of new hydroxyindolecarboxylate derivatives with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 16732-70-0 ethyl 5-bromoindolecarboxylate 
• 93-61-8 N-methyl-N-phenylformamide 
• 16382-11-9 ethyl 2-[2-(4-bromophenyl)hydrazinylidene]propanoate 
• 589-21-9 (4-bromophenyl)hydrazine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 153501-30-5 ethyl 5-bromo-3-hydroxyindole-2-carboxylate 
• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 

Relevant articles and documents

A concise synthesis of 3-hydroxyindole-2-carboxylates by a modified Baeyer-Villiger oxidation

Indole-2-carboxylates are converted in good yields to 3-hydroxyindole-2-carboxylates by use of a Vilsmeier-Haack/Baeyer-Villiger reaction sequence. A systematic examination of the various indole substituents revealed this route to be general in scope. (C) 2000 Published by Elsevier Science Ltd.

Design of C3-Alkenyl-Substituted 2-Indolylmethanols for Catalytic Asymmetric Interrupted Nazarov-Type Cyclization

The C3-alkenyl-substituted 2-indolylmethanols have been designed as a new class of substrates for catalytic asymmetric interrupted Nazarov-type cyclizations. In the presence of chiral phosphoric acid as a mild chiral Br?nsted acid, the interrupted Nazarov

INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein X1, Q, T, Y, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds

INDOLES USEFUL IN THE TREATMENT OF INFLAMATION

There is provided compounds of formula (I), Wherein T, Y, X1 , R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.