153501-30-5

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 5-bromo-3-hydroxy-1H-indole-2-carboxylate is used as a building block for the synthesis of pharmaceutical drugs. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Agrochemical Industry:
Ethyl 5-bromo-3-hydroxy-1H-indole-2-carboxylate is used as a building block for the synthesis of agrochemicals. Its chemical properties contribute to the development of effective agricultural products.
Used in Medicinal Chemistry Research and Development:
Ethyl 5-bromo-3-hydroxy-1H-indole-2-carboxylate is used as a research compound in the field of medicinal chemistry. Its unique structure and properties are utilized for the development of new drugs and treatments, contributing to advancements in healthcare and medicine.

InChI:InChI=1/C11H10BrNO3/c1-2-16-11(15)9-10(14)7-5-6(12)3-4-8(7)13-9/h3-5,13-14H,2H2,1H3

Upstream product

• 153501-29-2 ethyl N-<4-bromo-2-(ethoxycarbonyl)phenyl>glycinate 
• 100123-25-9 ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate 
• 16732-70-0 ethyl 5-bromoindolecarboxylate 
• 63243-76-5 2-amino-5-bromobenzoic acid,ethyl ester 

Relevant academic research and scientific papers

PDE IV inhibiting amides, compositions and methods of treatment

Compounds represented by formula I: as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by PDE-IV. Pharmaceutical compositions and methods of treatment are also included.

A concise synthesis of 3-hydroxyindole-2-carboxylates by a modified Baeyer-Villiger oxidation

Indole-2-carboxylates are converted in good yields to 3-hydroxyindole-2-carboxylates by use of a Vilsmeier-Haack/Baeyer-Villiger reaction sequence. A systematic examination of the various indole substituents revealed this route to be general in scope. (C) 2000 Published by Elsevier Science Ltd.

Synthesis, pharmacology and therapeutic potential of 10-methoxypyrazinoindoles, partial agonists at the 5HT2C receptor

A series of new 10-methoxypyrazinoindoles has been prepared and shown to be 5HT2C receptor ligands.The studied compounds 10a-j were found to act as partial agonists at the 5HT2C receptor, binding with high affinity and moderate selectivity versus 5HT1A and 5HT2A receptors, but inducing only a submaximal increase in phosphonoinositol formation.Compound 10j was demonstrated to be active in animal models of obsessive-compulsive disorder, depression and panic anxiety. - Keywords: pyrazinoindole; serotonin; 5HT2C receptor; partial agonist; psychiatric disorder.