100129-35-9

Basic information

• Product Name: 4-(2-chlorophenyl)piperidine
• Synonyms: 4-(2-chlorophenyl)piperidine;OTAVA-BB 1287675
• CAS NO: 100129-35-9
• Molecular Formula: C₁₁H₁₄ClN
• Molecular Weight: 195.692
• Mol File: 100129-35-9.mol

Chemical Properties

• Boiling Point: 276.3 °C at 760 mmHg
• Flash Point: 120.9 °C
• Appearance: /
• Density: 1.095 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.09±0.10(Predicted)
• CAS DataBase Reference: 4-(2-chlorophenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-chlorophenyl)piperidine(100129-35-9)
• EPA Substance Registry System: 4-(2-chlorophenyl)piperidine(100129-35-9)

Safety Data

• Hazardous Substances Data: 100129-35-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Chlorophenyl)piperidine is used as a key intermediate in the synthesis of various pharmaceutical drugs and research chemicals for its ability to react with other chemicals under controlled conditions.
Used in Drug Synthesis:
4-(2-Chlorophenyl)piperidine is used as a building block in the development of new drugs, particularly in the creation of local anesthetics like fentanyl, due to its unique chemical structure and reactivity.

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 99983-71-8 4-(2-chlorophenyl)piperidine-2,6-dione 
• 103857-58-5 3-(2-chlorophenyl)pentanedioic acid 
• 97429-95-3 4-(2-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride 
• 864830-05-7 tert-butyl 4-(2-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 615-41-8 2-iodochlorobenzene 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 108-90-7 chlorobenzene 

Relevant articles and documents

Design, synthesis and in vitro biological evaluation of isoxazol-4-carboxa piperidyl derivatives as new anti-influenza A agents targeting virus nucleoprotein

Influenza infection is a major cause of morbidity and mortality during seasonal epidemics and sporadic pandemics. It is important and urgent to develop new anti-influenza agents with a new mechanism of action. Nucleozin has been reported as a potent antagonist of nucleoprotein accumulation in the nucleus. In this study, a new series of isoxazol-4-carboxa piperidyl derivatives 1a-j were synthesized and their chemical structures were confirmed by 1H, 13C NMR and mass spectral data. Furthermore, all the synthesized compounds were evaluated for in vitro anti-influenza virus activity against influenza virus (A/PR/8/34 H1N1). Among all the compounds, 1a, 1b, 1c, 1f and 1g exhibited more potent activity than the standard drug, and compound 1b has showed most promising anti-influenza virus activity. These results are also consistent with the docking study results in terms of the design of compounds targeting influenza A via viral nucleoprotein.

TRIAZACYCLODODECANSULFONAMIDE ("TCD")-BASED PROTEIN SECRETION INHIBITORS

Provided herein are triazacyclododecansulfonamide ("TCD")-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.

Superacid-catalyzed preparation of aryl-substituted piperidines via dicationic electrophiles

The electrophilic chemistry of 1,2,3,6-tetrahydropyridines has been studied in the Bronsted superacid, CF3SO3H (triflic acid). The 1,2,3,6-tetrahydropyridines react with arenes to give aryl-substituted piperidines. It is proposed tha