Incineration, preferably after
mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove
the halo acids produced.
UN1134 Chlorobenzene, Hazard Class: 3;
Labels: 3-Flammable liquid.
Moderately toxic by ingestion and
intraperitoneal routes. Experimental
teratogenic and reproductive effects.
Mutation data reported. Strong narcotic with
slight irritant qualities. Dichlorobenzols are
strongly narcotic. Little is known of the
effects of repeated exposures at lower
concentrations, but it may cause hdney and
liver damage. The industrial illnesses
reported may possibly be due to
nitrobenzol. Dangerous fire hazard when
exposed to heat or flame. Moderate
explosion hazard when exposed to heat or
flame. Potentially explosive reaction with
powdered sodium or phosphorus trichloride
+ sodtum. Violent reaction with AgClO4.
Reacts vigorously with oxidizers. See also
AROMATIC. To fight fire, use foam, CO2,
dry chemical, water to blanket fire.
Associated with EPA Superfund sites
Flammable liquid; flash point (closed cup)
29°C (84°F); vapor pressure 8.8 torr at
20°C (68°F); autoignition temperature 638°C
(1180°F).Chlorobenzene vapors form explosive
mixtures with air within the range 1.3-7.1%
by volume in air. Dimethyl sulfoxide decom poses violently in contact with chloroben zene (NFPA 1997). Many metal perchlorates,
such as those of silver and mercury, may
form shock-sensitive solvated perchlorates
that may explode on impact.
Chlorobenzene is a monocyclic aromatic compound with one hydrogen atom on the benzene ring substituted with one chlorine. It is produced by chlorination of benzene in the liquid phase with a catalyst. Chlorobenzene is a colourless, flammable liquid with a sweet almond-like odor, at ambient temperature with a relatively high vapour pressure, moderate octanol-water partition coefficient (log 2.8) and moderate to low water solubility (497.9 mg/L @ 25℃). Chlorobenzene has a high solubility in nonpolar solvents, however, it is almost insoluble in water. Technical grade Chlorobenzene is typically 99% pure with < 0.05% benzene and < 0.1% dichlorobenzenes as contaminants. It is a common solvent and a widely used intermediate in the manufacture of other chemicals. Rhodococcus phenolicus is a bacterium species able to degrade chlorobenzene as sole carbon sources.
ChEBI: The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
Biological. In activated sludge, 31.5% of the applied chlorobenzene mineralized to carbon
dioxide after 5 d (Freitag et al., 1985). A mixed culture of soil bacteria or a Pseudomonas sp.
transformed chlorobenzene to chlorophenol (Ballschiter and Scholz, 1980). Pure microbial
cultures isolated from soil hydroxylated chlorobenzene to 2- and 4-chlorophenol (Smith and
Rosazza, 1974). Chlorobenzene was statically incubated in the dark at 25 °C with yeast extract and
settled domestic wastewater inoculum. At a concentration of 5 mg/L, biodegradation yields at the
end of 1 and 2 wk were 89 and 100%, respectively. At a concentration of 10 mg/L, significant
colourless liquid, Chlorination of benzene in the presence of a catalyst (FeCl3 or AICI3) yields chlorobenzene as the first product. Substitution with a second CI yields ortho, para, or meta dichlorobenzene, Eventually all the hydrogens can be substituted to give hexachlorobenzene, C6C16. In the presence ofultraviolet light, the chlorinationofbenzene yields benzene hexachloride, C6H6C~, a derivative ofcyclohexane.
Clear, colorless, flammable liquid with a sweet almond, medicinal or mothball-like odor. An odor
threshold concentration of 210 ppbv was reported by Leonardos et al. (1969). At 40 °C, the lowest
concentration at which an odor was detected was 190 μg/L. At 25 °C, the lowest concentration at
which a taste was detected was 190 μg/L (Young et al., 1996). The average least detectable odor
threshold concentration in water at 60 °C was 0.08 mg/L (Alexander et al., 1982). Cometto-Mu?iz
and Cain (1994) reported an average nasal pungency threshold concentration of 10,553 ppmv.
A possible carcinogen. Avoid inhalation
and skin contact. Moderate fire risk. Explosive limits 1.8–9.6%.
Journal of the American Chemical Society, 74, p. 6297, 1952 DOI: 10.1021/ja01144a523Tetrahedron Letters, 23, p. 371, 1982 DOI: 10.1016/S0040-4039(00)86833-1
Monochlorobenzene is used commercially as a solvent and to produce phenol and nitrochlorobenzenes.
Chlorobenzene, also called monochlorobenzene, is a monocyclic aromatic compound. It is a colorless liquid with an aromatic almond-like odor and is manufactured for use as a solvent, is used in the production of other chemicals (pesticides), and in making certain other chemicals, rubber, dyes and grease solvents. It is used as a feedstock to produce ortho- and para- nitrochlorobenzenes and aniline; as a solvent for paints; and as a heat transfer medium. In the past,Chlorobenzene was used as an intermediate in phenol and DDT production. Chlorobenzene enters the environment from industrial and municipal discharges. Another potential source is the formation and emission of Chlorobenzene as a product of incomplete combustion in waste incinerators. Chlorobenzene is moderately soluble in water; up to 1,000 milligrams will mix with a liter of water. Chlorobenzene is slightly persistent in water, with a half-life of between 2 to 20 days. Chlorobenzene persists in soil (several months), in air (3.5 days), and water (less than 1 day). When heated to decomposition this compound emits toxic fumes of hydrogen chloride gas, CO and CO2. Common synonyms are Monochlorobenzene, Benzene Chloride, and Chlorobenzol. It is incompatible with strong oxidizing agents and dimethyl sulfoxide. Chlorobenzene (also best known as monochlorobenzene or MCB) is a flammable liquid. Companies also use MCB to make adhesives, paints, paint removers, polishes, dyes, and drugs. In the past companies have used MCB to make phenol and related chemicals, pesticides (like DDT), and aniline. Chlorobenzene can evaporate when exposed to air. It dissolves slightly when mixed with water. Effects of chlorobenzene on human health and the environment depend on how much chlorobenzene is present and the length and frequency of exposure. Effects also depend on the health of a person or the condition of the environment when exposure occurs.
Chlorobenzene was not mutagenic in a
variety of bacterial and yeast assays. Existing
data suggest that genotoxicity may not be an
area of concern for chlorobenzene exposure in
Chlorobenzene undergoes a sometimes explosive reaction with powdered sodium or phosphorus trichloride + sodium. May react violently with dimethyl sulfoxide. Reacts vigorously with oxidizing agents. Attacks some forms of plastic, rubber and coatings. Forms a shock sensitive solvated salt with silver perchlorate. .
A colorless to clear, yellowish liquid with a sweet almond-like odor. Flash point 84°F. Practically insoluble in water and somewhat denser than water (9.2 lb / gal). Vapors heavier than air. Used to make pesticides, dyes, and other chemicals.
Air & Water Reactions
Highly flammable. Insoluble in water.
Irritating to skin, eyes and mucous membranes. Repeated exposure of skin may cause dermatitis due to defatting action. Chronic inhalation of vapors or mist may result in damage to lungs, liver, and kidneys. Acute vapor exposures can cause symptoms ranging from coughing to transient anesthesia and central nervous system depression.
Limited information is available on the acute (short-term) effects of chlorobenzene. Acute inhalation exposure of animals to chlorobenzene produced narcosis, restlessness, tremors, and muscle spasms. Chronic (long-term) exposure of humans to chlorobenzene affects the central nervous system (CNS). Signs of neurotoxicity in humans include numbness, cyanosis, hyperesthesia (increased sensation), and muscle spasms. No information is available on the carcinogenic effects of chlorobenzene in humans. EPA has classified chlorobenzene as a Group D, not classifiable as to human carcinogenicity.
The main impurities are likely to be chlorinated impurities originally present in the *benzene used in the synthesis of chlorobenzene, and also unchlorinated hydrocarbons. A common purification procedure is to wash it several times with conc H2SO4 then with aqueous NaHCO3 or Na2CO3, and water, followed by drying with CaCl2, K2CO3 or CaSO4, then with P2O5, and distilling. It can also be dried with Linde 4A molecular sieve. Passage through, and storage over, activated alumina has been used to obtain low conductance material. [Flaherty & Stern J Am Chem Soc 80 1034 1958, Beilstein 5 H 199, 5 IV 640.]
A colorless liquid made by
the catalytic reaction of chlorine with benzene.
It can be converted to phenol by reaction
with sodium hydroxide under
extreme conditions (300°C and 200 atmospheres
pressure). It is also used in the manufacture
of other organic compounds.
Chlorobenzene is used primarily as raw material for the synthesis of o- and p-nitrochlorobenzene and 2,4-dinitrochlorobenzene.Important quantitative chemical conversions other than the production of nitrochlorobenzenes are the production of diphenyl oxide and diphenyldichlorosilane.
Chlorobenzene is mainly used as raw material for the synthesis of chemicals including triphenylphosphine (catalyst for organic synthesis), phenylsilane, and thiophenol (pesticide and pharmaceutical intermediate). It is also used as raw material for the synthesis of solvent for organic synthesis reactions including methylenediphenyldiisocyanate, urethane raw material, agricultural adjuvants, paint and ink, and cleaning solvent for electronics.
manufacture of phenol, aniline, DDT; solvent for paints; heat transfer medium.
Chlorobenzene is used as a process solvent in the production of isocyanates such as MDI and TDI and as a solvent in various crop protection formulations. It is further used as a solvent in condensation reactions in the dyes industry.
Chlorobenzene is a basic substance used in chemical syntheses with 95% of the quantity used converted in closed systems to intermediate and final products.
It is used as a process solvent in the manufacture of three indigoid dyes and pigments. All the pigments and dyes are thioindigoid colors.
Chlorobenzene is an example of haloarenes which is formed by mono substitution of benzene ring. When chlorobenzene is fused with sodium hydroxide at 623K and 320 atm sodium phenoxide is produced. Finally, sodium phenoxide on acidification gives phenols.
Chlorobenzene is used in the manufacture of aniline, phenol, and chloronitrobenzene; as an intermediate in the manufacture of dyestuffs and many
pesticides, as a solvent; and emulsifier.
Chlorobenzene is used as a solvent for paints,as a heat transfer medium, and in the manu facture of phenol and aniline.
The toxic effects of chlorobenzene on humans were exhaustion, nausea, lethargy, headache and irritation to the upper respiratory tract and eye. Contact of chlorobenzene with the skin induced irritation. No reports were obtained on sensitization by chlorobenzene in this investigation.
The oral LD50 values of chlorobenzene were 1,445 mg/kg in mice, 1,427 to 3,400 mg/kg in rats and 2,250 to 2,830 mg/kg in rabbits. The LC50s following 6-hr inhalation exposure were 1,889 ppm in mice and 2,968 ppm in rats.
Manufacture of phenol, aniline, DDT; solvent for paint; color printing; dry cleaning industry.
Chlorobenzene is a halogenated benzene used in chemical toxicity QSAR research for agricultural pollution.
Reacts violently with strong oxidizers;
dimethyl sulfoxide; sodium powder; silver perchlorate;
causing fire and explosion hazard. Attacks some plastics,
rubber, and coatings. Decomposes on heating, producing
phosgene and hydrogen chloride fumes.