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1001409-50-2

PDK1 inhibitor is a chemical compound that specifically targets and inhibits the enzyme 3-phosphoinositide-dependent protein kinase-1 (PDK1), a key regulator of cellular processes such as cell growth, survival, and metabolism. By blocking PDK1 activity, these inhibitors have the potential to disrupt cancer cell proliferation, enhance insulin sensitivity, and modulate signaling pathways involved in disease progression, making them promising therapeutic agents for various medical conditions.

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  • 1001409-50-2 Structure

  • Basic information

    1. Product Name: PDK1 inhibitor
    2. Synonyms: PDK1 inhibitor;1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-;MP7
    3. CAS NO:1001409-50-2
    4. Molecular Formula: C28H22F2N4O4
    5. Molecular Weight: 516.4954864
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1001409-50-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 724.4±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.398
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: Soluble in DMSO
    9. PKA: 11.48±0.20(Predicted)
    10. CAS DataBase Reference: PDK1 inhibitor(CAS DataBase Reference)
    11. NIST Chemistry Reference: PDK1 inhibitor(1001409-50-2)
    12. EPA Substance Registry System: PDK1 inhibitor(1001409-50-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1001409-50-2(Hazardous Substances Data)

1001409-50-2 Usage

Uses

Used in Pharmaceutical Industry:
PDK1 inhibitor is used as a therapeutic agent for the treatment of cancer, as it can disrupt cancer cell proliferation by inhibiting the activity of PDK1, a key regulator of cell growth and survival.
PDK1 inhibitor is also used as a therapeutic agent for the treatment of diabetes, as it can enhance insulin sensitivity by blocking the activity of PDK1, which is involved in the regulation of cellular metabolism.
Additionally, PDK1 inhibitors are used in the research and development of drugs targeting other diseases, as they can modulate various signaling pathways involved in disease progression by inhibiting PDK1 activity. Ongoing research into PDK1 inhibitors aims to explore their potential as therapeutic agents for a range of medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1001409-50-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,4,0 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1001409-50:
(9*1)+(8*0)+(7*0)+(6*1)+(5*4)+(4*0)+(3*9)+(2*5)+(1*0)=72
72 % 10 = 2
So 1001409-50-2 is a valid CAS Registry Number.

1001409-50-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(3,4-difluorophenyl)methyl]-2-oxo-N-[(1R)-2-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)oxy]-1-phenylethyl]pyridine-3-carboxamide

1.2 Other means of identification

Product number -
Other names CS-0709

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1001409-50-2 SDS

1001409-50-2Downstream Products

1001409-50-2Relevant articles and documents

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Erlanson, Daniel A.,Arndt, Joseph W.,Cancilla, Mark T.,Cao, Kathy,Elling, Robert A.,English, Nicki,Friedman, Jessica,Hansen, Stig K.,Hession, Cathy,Joseph, Ingrid,Kumaravel, Gnanasambandam,Lee, Wen-Cherng,Lind, Ken E.,McDowell, Robert S.,Miatkowski, Konrad,Nguyen, Christine,Nguyen, Thinh B.,Park, Sophia,Pathan, Nuzhat,Penny, David M.,Romanowski, Michael J.,Scott, Daniel,Silvian, Laura,Simmons, Robert L.,Tangonan, Bradley T.,Yang, Wenjin,Sun, Lihong

, p. 3078 - 3083 (2011/06/26)

We report the use of a fragment-based lead discovery method, Tethering with extenders, to discover a pyridinone fragment that binds in an adaptive site of the protein PDK1. With subsequent medicinal chemistry, this led to the discovery of a potent and hig

PYRIDINONYL PDK1 INHIBITORS

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Page/Page column 100, (2008/06/13)

The present invention provides pyridinonyl PDKl inhibitors and methods of treating cancer using the same.

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