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1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride is a chemical compound characterized by the molecular formula C9H6ClNO2S. It is a significant building block in organic synthesis and medicinal chemistry, utilized for the creation of pharmaceutical intermediates and active pharmaceutical ingredients. 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride is recognized for its versatility in introducing the sulfonyl chloride functional group into organic molecules and serves as a protecting group for amines in synthesis processes. Moreover, it has demonstrated antitumor and anti-inflammatory properties, positioning it as a promising candidate for new drug development.

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  • 1001412-59-4 Structure
  • Basic information

    1. Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride
    2. Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride
    3. CAS NO:1001412-59-4
    4. Molecular Formula: C7H5ClN2O2S
    5. Molecular Weight: 216.6448
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1001412-59-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.70
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride(1001412-59-4)
    11. EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride(1001412-59-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1001412-59-4(Hazardous Substances Data)

1001412-59-4 Usage

Uses

Used in Organic Synthesis:
1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride is used as a versatile reagent for the introduction of the sulfonyl chloride functional group into organic molecules, facilitating a range of chemical reactions and the synthesis of complex organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride is employed as a building block for the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients, contributing to the development of new drugs with potential therapeutic applications.
Used as a Protecting Group in Organic Synthesis:
1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride is used as a protecting group for amines, which is crucial in organic synthesis to prevent unwanted reactions and ensure the selective formation of desired products.
Used in Drug Development:
Due to its reported antitumor and anti-inflammatory activities, 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride is used in the development of new drugs, particularly for conditions that may benefit from these therapeutic properties.
Used in Pharmaceutical Research:
In pharmaceutical research, 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride is utilized for exploring its potential as a lead compound in the discovery of novel therapeutic agents, given its demonstrated biological activities and chemical properties.

Check Digit Verification of cas no

The CAS Registry Mumber 1001412-59-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,4,1 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1001412-59:
(9*1)+(8*0)+(7*0)+(6*1)+(5*4)+(4*1)+(3*2)+(2*5)+(1*9)=64
64 % 10 = 4
So 1001412-59-4 is a valid CAS Registry Number.

1001412-59-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:1001412-59-4 SDS

1001412-59-4Upstream product

1001412-59-4Relevant articles and documents

In situ anionic shielding for regioselective metalation: Directed peri and iterative metalation routes to polyfunctionalized 7-azaindoles

Schneider, Cedric,David, Emilie,Toutov, Anton A.,Snieckus, Victor

supporting information; experimental part, p. 2722 - 2726 (2012/04/17)

Strolling the ring: A general regioselective directed peri(C4)-metalation route to 1 through an in situ N-anionic protection of C2 is reported. The azaindoles may be elaborated by directed ortho metalation (DoM) and Suzuki coupling to more complex heterocyclic systems. An iterative ring-walk DoM sequence furnishes the exhaustively substituted 2. DMG=directed metalation group, TMEDA=N,N,N′,N′-tetramethylethylenediamine, TMS=trimethylsilyl. Copyright

Design and synthesis of human immunodeficiency virus entry inhibitors: Sulfonamide as an isostere for the α-ketoamide group

Lu, Rong-Jian,Tucker, John A.,Zinevitch, Tatiana,Kirichenko, Olga,Konoplev, Vitalii,Kuznetsova, Svetlana,Sviridov, Sergey,Pickens, Jason,Tandel, Sagun,Brahmachary, Enugurthi,Yang, Yang,Wang, Jian,Freel, Stephanie,Fisher, Shelly,Sullivan, Alana,Zhou, Jiying,Stanfield-Oakley, Sherry,Greenberg, Michael,Bolognesi, Dani,Bray, Brian,Koszalka, Barney,Jeffs, Peter,Khasanov, Alisher,Ma, You-An,Jeffries, Cynthia,Liu, Changhui,Proskurina, Tatiana,Zhu, Tong,Chucholowski, Alexander,Li, Rongshi,Sexton, Connie

, p. 6535 - 6544 (2008/09/16)

The crystal structures of many tertiary α-ketoamides reveal an orthogonal arrangement of the two carbonyl groups. Based on the hypothesis that the α-ketoamide HIV attachment inhibitor BMS 806 (formally BMS378806, 26) might bind to its gp120 target via a s

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