1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride
• CAS No.: 1001412-59-4
• Molecular Formula: C7H5ClN2O2S
• Molecular Weight: 216.648
• Hs Code.: 2933990090
• Mol file: 1001412-59-4.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride

Chemical Property:

• PSA: 71.20000
• Density: 1.70
• LogP: 2.57120

Purity/Quality:

98%min ^*data from raw suppliers

1H-Pyrrolo[2,3-b]pyridine-3-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride

There total 1 articles about 1H-Pyrrolo[2,3-b]pyridine-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

7-Azaindole (271-63-6) → 1H-pyrrolo[2,3-b]pyridine-3-sulfonyl chloride (1001412-59-4)

Guidance literature:

With chlorosulfonic acid; at 0 - 120 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201108016

Reference yield: 57.0%

1H-pyrrolo[2,3-b]pyridine-3-sulfonyl chloride (1001412-59-4) + pyridin-3-ylmethyl 4-(4-aminobenzoyl)piperazine-1-carbodithioate → pyridin-3-ylmethyl 4-(4-(1H-pyrrolo[2,3-b]pyridine-3-sulfonamido)benzoyl) piperazine-1-carbodithioate

Guidance literature:

With pyridine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.bioorg.2021.104653

Reference yield: 31.0%

1H-pyrrolo[2,3-b]pyridine-3-sulfonyl chloride (1001412-59-4) + p-aminobenzophenone (99-92-3) → N-(4-acetylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-sulfonamide

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2017.11.023

upstream raw materials:

7-Azaindole

Downstream raw materials:

C₂₀H₂₂N₄O₃S

C₂₀H₂₂N₄O₃S

C₁₉H₁₉N₅O₄S

C₁₉H₁₉N₅O₄S

Refernces

• 1、 Lu, Rong-Jian,Tucker, John A.,Zinevitch, Tatiana,Kirichenko, Olga,Konoplev, Vitalii,Kuznetsova, Svetlana,Sviridov, Sergey,Pickens, Jason,Tandel, Sagun,Brahmachary, Enugurthi,Yang, Yang,Wang, Jian,Freel, Stephanie,Fisher, Shelly,Sullivan, Alana,Zhou, Jiying,Stanfield-Oakley, Sherry,Greenberg, Michael,Bolognesi, Dani,Bray, Brian,Koszalka, Barney,Jeffs, Peter,Khasanov, Alisher,Ma, You-An,Jeffries, Cynthia,Liu, Changhui,Proskurina, Tatiana,Zhu, Tong,Chucholowski, Alexander,Li, Rongshi,Sexton, Connie. "Design and synthesis of human immunodeficiency virus entry inhibitors: Sulfonamide as an isostere for the α-ketoamide group". . p. 6535 - 6544. Retrieved 2008/09/16.