Preparation of Polyfunctional Allenic Alcohols by the Regioselective Addition of Functionalized Propargylic Chromium(III) Organometallics to Carbonyl Compounds
The reaction of propargylic halides 1 (X = Cl, Br) with an aldehyde or ketone (0.67 equiv) in the presence of CrCl2 (2.0 equiv) and LiI (2 equiv, necessary if X = Cl) affords allenic alcohols 3 with excellent regioselectivities (3-6percent of the regioiso
Belyk, Kevin,Rozema, Michael J.,Knochel, Paul
p. 4070 - 4074
(2007/10/02)
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