100276-65-1

Basic information

• Product Name: ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate
• Synonyms: 3-quinolinecarboxylic acid, 6,7,8-trifluoro-1-(formylmethylamino)-1,4-dihydro-4-oxo-, ethyl ester; Ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS NO: 100276-65-1
• Molecular Formula: C₁₄H₁₁F₃N₂O₄
• Molecular Weight: 328.2433
• Mol File: 100276-65-1.mol

Chemical Properties

• Boiling Point: 429.5°C at 760 mmHg
• Flash Point: 213.6°C
• Density: 1.49g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate(100276-65-1)
• EPA Substance Registry System: ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate(100276-65-1)

Safety Data

• Hazardous Substances Data: 100276-65-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate is used as an active pharmaceutical ingredient for the development of new drugs, leveraging its complex molecular structure to target specific biological pathways or receptors. Its unique functional groups may allow for modulation of various physiological processes, offering potential therapeutic benefits in treating diseases.
Used in Chemical Research:
In the field of chemical research, ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate serves as a subject for studying the effects of fluorination on molecular properties and reactivity. Its synthesis and modification can provide insights into the development of new synthetic routes and the exploration of novel chemical reactions.
Used in Material Science:
Ethyl 6,7,8-trifluoro-1-[formyl(methyl)amino]-4-oxo-1,4-dihydroquinoline-3-carboxylate may be utilized in material science for the creation of new compounds with specific properties, such as enhanced stability, solubility, or reactivity. Its incorporation into polymers or other materials could lead to advancements in various applications, including coatings, sensors, or catalysts.

Upstream product

• 100276-64-0 2-(2,3,4,5-Tetrafluorbenzoyl)-3-(2-formyl-2-methylhydrazino)acrylsaeure-ethylester 
• 94714-58-6 ethyl 2-(ethoxymethylene)-3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate 
• 103994-82-7 ethyl 3-ethoxy-2-(2,3,4,5-tetra-fluorobenzoyl)-acrylate 
• 2414-98-4 magnesium ethylate 
• 7757-82-6 sodium sulfate 
• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 

Downstream Products

• 100276-37-7 6,8-Difluor-1-(methylamino)-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeure 
• 158585-86-5 ethyl 6,8-difluoro-1,4-dihydro-1-(N-methylformamido)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylate 

Relevant articles and documents

Process for the manufacture of a tricyclic compound

A process for preparing a compound of formula (I) or a phamaceutically-acceptable salt thereof, comprising: 1) reacting a compound. of formula (III), in which R is a straight or branched chain alkyl having from one to four carbon atoms, with an alkali metal hydroxide in an aqueous medium at a temperature of about 80° to 120° C. and time of about 20 to 100 hours to form a reaction product; 2) cyclizing the reaction product of step 1) with formic acid and formaldehyde to form a formiate compound; and 3) neutralizing the formiate compound of step 2) with an aqueous base.

Cycloaracylation of Enamines,II. - Synthesis of 1-Amino-4-quinolone-3-carboxylic Acids

The 2-benzoyl-3-hydrazinoacrylic esters 3, 11, 17, and 23 are obtained by the reactions of 2-chloro-5-nitrobenzoyl chloride (1) with the enehydrazinocarboxylic esters 2 and 2-benzoyl-3-ethoxyacrylic esters 9 with hydrazine derivatives 10, 16, and 22.After cyclocondensation, the above esters afford 1-aminoquinolonecarboxylic esters 4, 12, 18, and 24, which are hydrolyzed to give the corresponding 1-aminoquinolonecarboxylic acids 5, 13, 19, and 26.The 1-amino-7-haloquinolonecarboxylic acids 13a-f, 19a-f, and 26b react with aliphatic amines to afford 1,7-diaminoquinolonecarboxylic acids 30c-m, which possess a high level of bactericidal activity.

Antibacterial 1,7-diamino-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

Antibacterially effective 1,7-diamino-1,4-dihydro-4-oxo-3-(aza)quinolinecarboxylic acids of the formula STR1 in which A is nitrogen or C--R1, R1 is nitro or halogen, R2 and R3 each independently is C1