100278-67-9Relevant articles and documents
Investigating the microwave-accelerated Claisen rearrangement of allyl aryl ethers: Scope of the catalysts, solvents, temperatures, and substrates
Hui, Zi,Jiang, Songwei,Qi, Xiang,Ye, Xiang-Yang,Xie, Tian
supporting information, (2020/05/18)
The microwave-accelerated Claisen rearrangement of allyl aryl ethers was investigated, in order to gain insight into the scope of the catalysts, solvents, temperatures, and substrates. Among the catalysts examined, phosphomolybdic acid (PMA) was found to greatly accelerate the reaction in NMP, at temperatures ranging from 220 to 300 °C. This method was found to be useful for preparing several intermediates previously reported in the literature using precious metal catalysts such as Au(I), Ag(I), and Pt(II). Additionally, substrates bearing bromo and nitro groups on the aryl portion required careful tailoring of the reaction conditions to avoid complex product profiles.
FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS
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Page/Page column 71, (2010/10/20)
Compounds of formula (I) wherein R1, R2, X, A, Y, B, Z1, Q, p, r and s are defined in the specification for treating inter alia psychotic disorders, depressive disorders, anxiety disorders and sexual dysfunctions.
Phenolic P2/P3 core motif as thrombin inhibitors - Design, synthesis, and X-ray co-crystal structure
Hanessian, Stephen,Therrien, Eric,Van Otterlo, Willem A. L.,Bayrakdarian, Malken,Nilsson, Ingemar,Fjellstr?m, Ola,Xue, Yafeng
, p. 1032 - 1036 (2007/10/03)
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
Solid-state regioselective nitration of activated hydroxyaromatics and hydroxycoumarins with cerium (IV) ammonium nitrate
Ganguly, Nemai C.,Dutta, Sanjoy,Datta, Mrityunjoy,De, Prithwiraj
, p. 733 - 735 (2007/10/03)
Predominant ortho-selective mononitration of low-melting and liquid phenols and hydroxycoumarins in moderate to high yields has been accomplished upon grinding with solid cerium (IV) ammonium nitrate (CAN). Microwave-assisted expeditious CAN-mediated nitration of relatively high melting phenols and hydroxycoumarins with high efficiency and selectively under solvent-free conditions has been also developed to address the problems of sluggishness and low yield for these reluctant substrates.
Aminopyridinyl-, aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors
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, (2008/06/13)
Phenyl acetamide compounds are described, including compounds of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compound
Miticidal 2-(2-methyl-2,3-dihydro-benzofuran-7-yl)hydrazinecarboxylic acid esters
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, (2008/06/13)
Certain miticidal 2-(2-alkyl-2,3-dihydro-benzofuran-7-yl)-hydrazinecarboxylic acid esters.
(2-Substituted-2,3-dihydrobenzo-furan-7-yl)diazenecarboxylic acid esters and miticidal method
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, (2008/06/13)
Certain miticidal (2-substituted-2,3-dihydro-benzofuran-7-yl)diazenecarboxylic acid esters.