409082-21-9Relevant academic research and scientific papers
Phenolic P2/P3 core motif as thrombin inhibitors - Design, synthesis, and X-ray co-crystal structure
Hanessian, Stephen,Therrien, Eric,Van Otterlo, Willem A. L.,Bayrakdarian, Malken,Nilsson, Ingemar,Fjellstr?m, Ola,Xue, Yafeng
, p. 1032 - 1036 (2006)
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
Aminopyridinyl-, aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors
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, (2008/06/13)
Phenyl acetamide compounds are described, including compounds of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compound
