Regioselective copper-catalyzed C-N and C-S bond formation using amines, thiols and halobenzoic acids
A regioselective method for highly efficient C-N and C-S bond formation with 2-halobenzoic acids is described. The Cu/Cu2O-catalyzed reaction is carried out in 2-ethoxyethanol or ethylene glycol diethyl ether and does not require the use of strong base or other additives. This procedure eliminates the need for acid protection, tolerates a wide range of functional groups and provides aromatic and aliphatic amines and sulfides in 81-99% yield. Georg Thieme Verlag Stuttgart.
Liu, Shuanglong,Pestano, John Paul C.,Wolf, Christian
p. 3519 - 3527
(2008/09/19)
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