- A acrinol pharmaceutical intermediate 2 - chloro -4 - nitro benzoic acid (by machine translation)
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A acrinol pharmaceutical intermediate 2 - chloro - 4 - nitro-benzoic acid, mainly comprising the following steps: in the reaction container by adding 3 μM of 2 - chloro - 4 - nitro - 6 - hydroxy - cumene, 4 - 6 μM of N - methyl morpholine solution, raising the temperature of the solution to 40 — 46 °C, the stirring speed is 170 — 190 rpm, maintaining 50 — 70 min after, adding 6 μM four n propyl titanate, raising the temperature of the solution to 50 — 55 °C, reflux 90 — 110 min, reduce the temperature of the solution to 10 — 15 °C, separating solid, filtering, solid allylamine solution washing, using the oxalic acid solution to adjust the pH to 3 - 4, reduced in temperature to 5 — 8 °C, separating out crystal, filtering, salicylic acid methyl ester solution for washing, dehydrating agent dehydration, to get the finished product 2 - chloro - 4 - nitro-benzoic acid. (by machine translation)
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Paragraph 0010; 0012-0014
(2018/10/19)
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- Combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid
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The invention discloses a combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid. The method comprises the following steps: (1) oxidation: a step of continuously introducing substituted toluene, a catalyst and oxygen-contained gas into an oxidation reactor and carrying out reaction so as to obtain oxidation reaction liquid; (2) hydrolyzation: a step of allowing the oxidation reaction liquid to continuously enter a hydrolysis reactor, and continuously adding water into the hydrolysis reactor and carrying out reaction so as to obtain a hydrolysis reaction mixture; (3) liquid-liquid layering: a step of layering the hydrolysis reaction mixture so as to obtain an oil phase and an aqueous phase; and (4) separation of products: a step of subjecting the oil phase to distillation so as to respectively obtain incompletely-reacted substituted toluene, substituted benzyl alcohol and substituted benzaldehyde, and subjecting the aqueous phase to cooling, crystallizing and filtering so as to obtain filtrate and substituted benzoic acid. The combined production method provided by the invention has the advantages of high raw material conversion rate, few by-products, good selectivity of target products, greenness and environmental protection.
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Paragraph 0081; 0082
(2017/01/31)
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- Bio-derived CuO nanocatalyst for oxidation of aldehyde: A greener approach
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Eco-friendly synthesis of hierarchical CuO nanoparticles using the peel of Musa balbisiana and its application as a nanocatalyst in oxidation of aldehyde to the corresponding carboxylic acid is reported here. CuO nanoparticles were characterized by using XRD, XPS, SEM, TEM and PL techniques. In XRD analysis, significant peaks appeared at 18.2, 24.6, 33.3, 34.9, 35.5, 38.6 and 42.3. The SEM images indicate the formation of a micro flower hierarchical CuO architecture. The hierarchical CuO architecture is found to be made up of 2D nanosheets as building blocks, which were self assembled to form micro flower like assemblies. The synthesized CuO nanoparticles are efficiently utilised in the oxidation of aldehyde to the corresponding carboxylic acid in the presence of 30% H2O2 with high yields. The utilization of the CuO nanocatalyst in the oxidation reaction in environmental friendly conditions is the novelty in this study. This journal is the Partner Organisations 2014.
- Tamuly, Chandan,Saikia, Indranirekha,Hazarika, Moushumi,Das, Manash R.
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p. 20636 - 20640
(2014/06/09)
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- KINETICS AND MECHANISM OF THE IMIDAZOLE-CATALYSED HYDROLYSIS OF SUBSTITUTED N-BENZOYLIMIDAZOLES
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Imidazole (Imz)-catalysed hydrolysis of benzoate esters proceeds via the intermediate formation of N-benzoylimidazoles.This paper considers the second step of this reaction, viz., Imz-catalysed hydrolysis of N-(4-X-benzoyl)imidazoles, X = CH3, H, Cl, CN and NO2, and N-(disubstituted benzoyl)imidazoles, 2-chloro-4-nitro, 2,4-dinitro and 3,5-dinitro, in water-acetonitrile mixtures (10percent or 14percent, v/v, in organic solvent).On the basis of catalytic rate constants and the kinetic solvent isotope effect, it is shown that catalysis by Imz is of the general-base type.Unexpectedly, the hydrolysis of N-(2,4-dinitrobenzoyl)imidazole was found to be slower than that of N-(4-nitrobenzoyl)imidazole.It is shown that this reactivity order is due to a combination of a steric effect and stabilization of the reactant state due to a donor-acceptor interaction between the Imz moiety and the 2,4-dinitrophenyl ring.
- Seoud, Omar A. El,Menegheli, Paulo,Pires, Paulo A. R.,Kiyan, Nilo Z.
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p. 431 - 436
(2007/10/02)
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