100367-38-2

Basic information

• Product Name: no
• Synonyms: 3-AMino-5-broMophenol;3-Amino-5-bromophenol 97%;3-Bromo-5-hydroxyaniline;3-broMo-5-aMinophenol;3-Amino-5-bromophenol97%
• CAS NO: 100367-38-2
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02194
• Mol File: 100367-38-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: no(CAS DataBase Reference)
• NIST Chemistry Reference: no(100367-38-2)
• EPA Substance Registry System: no(100367-38-2)

Safety Data

• Hazardous Substances Data: 100367-38-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Amino-5-bromophenol is utilized as an intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents. Its unique structure allows it to be a key component in the creation of molecules with potential medicinal properties.
Used in Dye Industry:
In the dye industry, 3-Amino-5-bromophenol serves as an intermediate in the production of azo dyes, which are a class of synthetic dyes known for their wide range of colors and applications in various fields, including textiles, plastics, and printing inks.
Used in Organic Synthesis:
3-Amino-5-bromophenol is employed as a building block in organic synthesis, enabling the creation of a variety of organic compounds for different applications across multiple industries. Its reactivity and structural features make it a valuable precursor in the synthesis of complex organic molecules.

Upstream product

• 121-88-0 5-Nitro-2-aminophenol 
• 16618-68-1 3-bromo-5-methoxyaminobenzene 
• 116632-23-6 3-bromo-5-nitro-phenol 

Downstream Products

• 1085526-12-0 3-bromo-5-[[6-[[(R)-methyloxidophenyl-λ4-sulphanylidene]amino]quinolin-4-yl]amino]phenol 

Relevant articles and documents

Discovery of meta-amido bromophenols as new antitubercular agents

A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant strains. The compounds did not show inhibitory activity against normal Gram-positive and Gram-negative bacteria. Moderate cytotoxicities and good metabolic stability were observed for the selected compounds. The results demonstrated meta-amido bromophenols as a new class of antitubercular agents with good potentials.

Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents

The first direct activator of BAX, a pro-apoptotic member of the BCL-2 family, has been recently identified. Herein, a structure-based lead optimization turned out into a small series of analogues, where 8 is the most potent compound published so far. 8 was used as pharmacological tool to ascertain, for the first time, the anticancer potential of BAX direct activators and the obtained results would suggest that BAX direct activators are potential future anticancer drugs rather than venoms.

TRPV4 ANTAGONISTS

The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.