16618-68-1

Usage

Uses

Used in Organic Synthesis:
3-bromo-5-methoxyaniline is utilized as a key intermediate in organic synthesis for the creation of a wide range of complex organic molecules. Its unique structure allows it to participate in various chemical reactions, facilitating the development of new compounds with diverse applications.
Used in Pharmaceutical Research and Drug Development:
In the pharmaceutical industry, 3-bromo-5-methoxyaniline is employed as a building block in the production of various pharmaceutical compounds. Its potential use in the development of new drugs makes it a compound of significant interest to researchers and scientists working in medicinal chemistry. 3-bromo-5-methoxyaniline's reactivity and structural features contribute to the design and synthesis of novel therapeutic agents.
Used in Medicinal Chemistry:
3-bromo-5-methoxyaniline is of interest to researchers in the pharmaceutical and biotechnology industries due to its potential applications in medicinal chemistry. Its ability to be modified and incorporated into different molecular frameworks positions it as a promising candidate for the discovery and development of innovative pharmaceuticals with improved efficacy and selectivity.

Upstream product

• 16618-67-0 3-bromo-5-nitroanisole 
• 99-65-0 meta-dinitrobenzene 
• 18242-39-2 3,5-dinitrobromobenzene 

Downstream Products

• 102236-51-1 3-bromo-5-methoxy-N,N-dimethylaniline 
• 62606-12-6 (3-Bromo-5-methoxy-phenyl)-(2,4,6-trinitro-phenyl)-amine 
• 106120-04-1 5-bromoresorcinol 
• 938061-52-0 (3-Bromo-5-methoxy-phenyl)-(2,2-diethoxy-ethyl)-amine 
• 1261677-80-8 7-bromo-5-hydroxy-quinoline 
• 1610628-06-2 N-(3-bromo-5-methoxyphenyl)-3-methoxyacrylamide 

Relevant academic research and scientific papers

TEAD INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

M-di-substituted phenol compound as well as preparation method thereof and application of tubercle bacillus resistance

The invention provides an m-di-substituted phenol compound with a general formula (I) as well as a preparation method and application thereof. The m-di-substituted phenol compound provided by the invention has a novel tubercle bacillus resistance drug parent nucleus structure and excellent tubercle bacillus resistance activity and especially has very strong inhibition activity on a drug-resistantvariant tubercle bacillus strain. The invention further provides the preparation method of the m-di-substituted phenol compound; the preparation method has the advantages that raw materials are cheapand easy to obtain, a high-toxicity and high-pollution reagent are not needed, reaction steps are simple and industrialized production can be realized; the m-di-substituted phenol compound has a goodmedicinal prospect.

Synthesis of 1,5-bifunctional organolithium reagents by a double directed ortho-metalation: Direct transformation of esters into 1,8-dimethoxy-acridinium salts

The impact of electronic and steric factors on the selectivity of the electrophilic aromatic substitution amounts to several limitations in accessing specific substitution patterns. Nucleophiles generated by directed metalation represent an effective alte

Indole and quinoline derivatives and its preparation method and application

The invention provides an indoloquinoline derivative, a preparation method and application thereof in preparing antitumor drugs and antiviral drugs. The chemical structure of the indoloquinoline derivative is shown as a formula I. Experiments show that a partly-boric-acid-modified indoloquinoline derivative and a non-boric-acid-modified indoloquinoline derivative have strong inhibition effect on various tumor cell strains, thereby being capable of being used for preparation of the antitumor drugs, and have strong antiviral activity, thereby being capable of being used for preparation of the antiviral drugs.

Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B2pin2 in Isopropanol

A metal-free reduction of aromatic nitro compounds to the corresponding amines has been achieved by a combination of B2pin2 and KOtBu in isopropanol. A series of nitro compounds containing various reducible functional groups were chemoselectively reduced in good to excellent yields.

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against mycobacterium tuberculosis

DNA gyrase is a clinically validated target for developing drugs against Mycobacterium tuberculosis (Mtb). Despite the promise of fluoroquinolones (FQs) as anti-tuberculosis drugs, the prevalence of pre-existing resistance to FQs is likely to restrict their clinical value. We describe a novel class of N-linked aminopiperidinyl alkyl quinolones and naphthyridones that kills Mtb by inhibiting the DNA gyrase activity. The mechanism of inhibition of DNA gyrase was distinct from the fluoroquinolones, as shown by their ability to inhibit the growth of fluoroquinolone-resistant Mtb. Biochemical studies demonstrated this class to exert its action via single-strand cleavage rather than double-strand cleavage, as seen with fluoroquinolones. The compounds are highly bactericidal against extracellular as well as intracellular Mtb. Lead optimization resulted in the identification of potent compounds with improved oral bioavailability and reduced cardiac ion channel liability. Compounds from this series are efficacious in various murine models of tuberculosis.

3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.