100367-78-0

Basic information

• Product Name: 1-(2-bromo-5-nitrophenyl)hydrazine
• Synonyms: 1-(2-bromo-5-nitrophenyl)hydrazine;(2-bromo-5-nitrophenyl)hydrazine
• CAS NO: 100367-78-0
• Molecular Formula: C₆H₆BrN₃O₂
• Molecular Weight: 232.03474
• Mol File: 100367-78-0.mol

Chemical Properties

• Boiling Point: 331.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.869±0.06 g/cm3(Predicted)
• PKA: 3.75±0.10(Predicted)
• CAS DataBase Reference: 1-(2-bromo-5-nitrophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-5-nitrophenyl)hydrazine(100367-78-0)
• EPA Substance Registry System: 1-(2-bromo-5-nitrophenyl)hydrazine(100367-78-0)

Safety Data

• Hazardous Substances Data: 100367-78-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-bromo-5-nitrophenyl)hydrazine is used as a reagent in the pharmaceutical industry for the preparation of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Production:
In the agrochemical industry, 1-(2-bromo-5-nitrophenyl)hydrazine is utilized as a reagent for the synthesis of different agrochemicals. Its role in creating these compounds aids in enhancing agricultural productivity and crop protection.
Used in Material Science:
1-(2-bromo-5-nitrophenyl)hydrazine is also employed in material science as a reagent for the development of new materials. Its incorporation into the synthesis process can lead to the creation of materials with improved properties, such as enhanced stability or specific functional characteristics.

Upstream product

• 10403-47-1 2-bromo 5-nitroaniline 

Downstream Products

• 159547-14-5 2-(2-bromo-5-nitrophenyl)-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 100874-24-6 piperonal-(2-bromo-5-nitro-phenylhydrazone) 
• 98273-65-5 formaldehyde-(2-bromo-5-nitro-phenylhydrazone) 
• 847233-84-5 7-bromo-3-(4-chlorophenoxy)-2-methyl-4-nitro-1H-indole-1-acetic acid 1,1 dimethylethyl ester 
• 847233-86-7 3-(4-chlorophenoxy)-2-methyl-4-[(methylsulfonyl)amino]-1H-indole-1-acetic acid, 1,1-dimethylethyl ester 
• 847233-88-9 4-acetylamino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester 
• 847233-85-6 4-amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester 

Relevant articles and documents

FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton’ s tyrosine kinase (Btk), and for treating disorders mediated thereby.

Novel Anthranilic Diamide Scaffolds Containing N-Substituted Phenylpyrazole as Potential Ryanodine Receptor Activators

To discover potent insecticides targeting ryanodine receptors (RyRs), a series of novel anthranilic diamides analogues (12a-12u) containing N-substituted phenylpyrazole were designed and synthesized. These compounds were characterized by 1H NMR, 13C NMR, and HRMS, and the structure of compound 12u was confirmed by X-ray diffraction. Their insecticidal activities indicated that these compounds displayed moderate to excellent activities. In particular, 12i showed 100 and 37% larvicidal activities against oriental armyworm (Mythimna separata) at 0.25 and 0.05 mg L-1, equivalent to that of chlorantraniliprole (100%, 0.25 mg L-1; and 33%, 0.05 mg L-1). The activity of 12i against diamondback moth (Plutella xylostella) was 95% at 0.05 mg L-1, whereas the control was 100% at 0.05 mg L-1. The calcium-imaging technique experiment results showed that the effects of 12i on the intracellular calcium ion concentration ([Ca2+]i) in neurons were concentration-dependent. After the central neurons of Helicoverpa armigera were dyed by loading with fluo-5N and treated with 12i, the free calcium released in endoplasmic reticulum indicated the target of compound 12i is RyRs or IP3Rs. The activation of RyRs by natural ryanodine completely blocked the calcium release induced by 12i, which indicated that RyRs in the central neurons of H. armigera third-instar larvae is the possible target of compound 12i.

FUSED HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby.

Substituted tetrahydro-1H-pyrido[4,3-b]indoles as serotonin receptors agonists and antagonists

The present application describes compounds, including all pharmaceutically acceptable salts, prodrugs, solvates and stereoisomers thereof, according to Formula I, pharmaceutical compositions, comprising at least one compound according to Formula I and optionally at least one additional therapeutic agent and methods of treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using compounds according to Formula I

SUBSTITUTED INDOLE DERIVATIVES FOR PHARMACEUTICAL COMPOSITION FOR TREATING RESPIRATORY DISEASES

The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders.