Gold(I) Complexes Stabilized by Nine- and Ten-Membered N-Heterocyclic Carbene Ligands
Nine- and ten-membered N-heterocyclic carbene (NHC) ligands have been developed and for the first time their gold(I) complexes were synthesized. The protonated NHC pro-ligands 2 a–h were prepared by the reaction of readily available N,N′-diarylformamidines with bis-electrophilic building blocks, followed by anion exchange. In situ deprotonation of the tetrafluoroborates 2 a–h with tBuOK in the presence of AuCl(SMe2) provided fast access to NHC-gold(I) complexes 3–10. These new NHC-gold(I) complexes show very good catalytic activity in a cycloisomerization reaction (0.1 mol % catalyst loading, up to 100 % conversion) and their solid-state structures reveal high steric hindrance around the metal atom (%Vbur up to 53.0) which is caused by their expanded-ring architecture.
Cervantes-Reyes, Alejandro,Rominger, Frank,Rudolph, Matthias,Hashmi, A. Stephen K.
Study on the intramolecular transannular chalcogen-tin interactions in dithiastannecine compounds
Dithiastannecine compounds of the type [{D(C6H 4CH2S)2}SnR1R2] with different donor atoms D were prepared, where D = O and R1 = R 2 = Ph (4a); R1 = Ph, Rsu
Martinez-Otero, Diego,Alvarado-Rodriguez, Jose G.,Cruz-Borbolla, Julian,Andrade-Lopez, Noemi,Pandiyan, Thangarasu,Moreno-Esparza, Rafael,Flores-Alamo, Marcos,Cantillo-Castillo, Jesus
experimental part
p. 367 - 377
(2012/03/13)
Potential Antitumor Agents. 62. Structure Activity Relationships for Tricyclic Compounds Related to the Colon Tumor Active Drug 9-Oxo-9H-xanthene-4-acetic Acid
A series of tricyclic analogues of 9-oxo-9H-xanthene-4-acetic acid have been prepared and evaluated for their ability to cause homorrhagic necrosis in subcutaneously implanted colon 38 tumors in mice, in an effort to extend the structure-activity relation
Rewcastle, Gordon W.,Atwell, Graham J.,Palmer, Brian D.,Boyd, Peter D. W.,Baguley, Bruce C.,Denny, William A.
p. 491 - 496
(2007/10/02)
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