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Formaldehyde, also known as methyl aldehyde or methylene oxide, is a colorless, flammable gas with a distinct, pungent odor. It is the simplest aldehyde, a class of organic compounds with the carbonyl group bonded to at least one hydrogen atom. Formaldehyde is highly soluble in water and in a variety of organic solvents. It readily dissolves in water to produce a solution called formalin, which is commonly marketed as a 37% solution. Formaldehyde is used widely by the chemical industry to manufacture building materials and numerous household products. It is also a by-product of combustion and certain other natural processes.

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  • 50-00-0 Structure
  • Basic information

    1. Product Name: Formaldehyde
    2. Synonyms: ALDEHYDE C1;TREATMENT OF FORMALIN;Aldehyd mravenci;Aldehyde formique;aldehydeformique;aldehydmravenci;Aldeide formica;aldeideformica
    3. CAS NO:50-00-0
    4. Molecular Formula: CH2O
    5. Molecular Weight: 30.03
    6. EINECS: 200-001-8
    7. Product Categories: Biocides;Chemistry;Aldehydes;Building Blocks;C1 to C6;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Amber Glass Bottles;Cancer Research;Carcinogens;Histological;Solvent Bottles;Solvent Packaging Options;Solvents;Pharmaceutical raw materials
    8. Mol File: 50-00-0.mol
    9. Article Data: 1565
  • Chemical Properties

    1. Melting Point: -15°C
    2. Boiling Point: 97°C(37% solution),-19.5°C(pure)
    3. Flash Point: 133 °F
    4. Appearance: APHA: ≤10/Solution
    5. Density: 1.09 g/mL at 25 °C(lit.)
    6. Vapor Density: 1.03 (vs air)
    7. Vapor Pressure: 52 mm Hg ( 37 °C)
    8. Refractive Index: n20/D 1.377
    9. Storage Temp.: 2-8°C
    10. Solubility: water: soluble
    11. PKA: 13.27(at 25℃)
    12. Water Solubility: soluble
    13. Merck: 14,4235
    14. BRN: 1209228
    15. CAS DataBase Reference: Formaldehyde(CAS DataBase Reference)
    16. NIST Chemistry Reference: Formaldehyde(50-00-0)
    17. EPA Substance Registry System: Formaldehyde(50-00-0)
  • Safety Data

    1. Hazard Codes: T
    2. Statements: 23/24/25-34-40-43-39/23/24/25-68-45-68/20/21/22
    3. Safety Statements: 36/37-51-45-36/37/39-26-53
    4. RIDADR: UN 1198 3/PG 3
    5. WGK Germany: 2
    6. RTECS: LP8925000
    7. F: 10
    8. TSCA: Yes
    9. HazardClass: 3
    10. PackingGroup: III
    11. Hazardous Substances Data: 50-00-0(Hazardous Substances Data)

50-00-0 Usage

Uses

Used in Chemical Industry:
Formaldehyde is used as a chemical intermediate for the production of phenolic resins, cellulose esters, artificial silk, dyes, explosives, and organic chemicals. It is also used in the manufacture of urea, phenolic melamine, and acetale resins.
Used in Medical Laboratories and Embalming:
Formaldehyde is used as a preservative, disinfectant, and antiseptic in medical laboratories and embalming solutions. It is also used as a tissue fixative.
Used in Building Materials and Household Products:
Formaldehyde is used in the production of plastics and resins, such as urea-formaldehyde (UF) and phenol-formaldehyde (PF) resins, which are used in foam insulations, adhesives in the production of particle board and plywood, and in the treating of textiles.
Used in Agriculture:
Formaldehyde is used as a microbiocide, fungicide, and bactericide in agriculture. It is also used as a soil sterilent and as a pesticide intermediate.
Used in Textile Industry:
Formaldehyde is used to improve the fastness of dyes on fabrics, in tanning and preserving hides, and in mordanting and waterproofing fabrics.
Used in Cosmetics and Personal Care Products:
Formaldehyde is used as an astringent, disinfectant, and preservative in cosmetics, metal-working fluids, shampoos, and as an antiperspirant.
Used in Other Industries:
Formaldehyde is used in the production of pentaerythritol, hexamethylenetetramine, and lkbutanediol. It is also used in ceiling and wall insulation, resins used to wrinkle-proof fabrics, photography for hardening gelatin plates and papers, toning gelatin-chloride papers, and for chrome printing and developing.
Environmental and Health Considerations:
Formaldehyde is directly emitted into the air from vehicles and is released in trace amounts from pressed wood products, old buildings, and certain fabrics. It is also a toxic effluent gas emitted from burning wood and synthetic polymeric substances. Precautions and protections must be considered during its use due to links between formaldehyde and adverse health effects.

History

Formaldehyde is a by-product of combustion of organic compounds, metabolism, and other natural processes. Formaldehyde results from wood combustion and elevated atmospheric concentrations can result from forest fires, as well as from urban pollution sources such as transportation. Formaldehyde has been identified as a significant indoor air pollutant. Building materials such as particleboard, plywood, and paneling are major sources of formaldehyde because they incorporate formaldehyde resins as bonding adhesives. Other sources of formaldehyde in the home are carpets, upholstery, drapes, tobacco smoke, and indoor combustion products. Formaldehyde may be emitted from building materials for several years after installation. In the two decades of the 1960s and 1970s, a half million homes in the United States used urea formaldehyde foam insulation, but health complaints led to its elimination as an insulator in the early 1980s. People react differently to formaldehyde exposure, but it is estimated that between 10% and 20% of the population will experience some reaction at concentrations as low as 0.2 parts per million. Formaldehyde irritates the eyes, nose, and throats, producing coughing, sneezing, runny nose, and burning eyes. More severe reactions result in insomnia, headaches, rashes, and breathing difficulties. Some states have established indoor air quality standards ranging from 0.05 to 0.5 ppm.

Production Methods

The industrial preparation of formaldehyde has occurred since the late 1800s and involvesthe catalytic oxidation of methanol: 2CH3OH(g) + O2(g) → 2CH2O(g).the oxidationtakes place at temperatures between 400°C and 700°C in the presence of metal catalysts. Metalsinclude silver, copper, molybdenum, platinum, and alloys of these metals. Formaldehyde iscommonly used as an aqueous solution called formalin. Commercial formalin solutions varybetween 37% and 50% formaldehyde. When formalin is prepared, it must be heated anda methanol must be added to prevent polymerization; the final formalin solution containsbetween 5% and 15% alcohol.

Preparation

Formalin is adjusted to pH 8 and urea is added to give a urea to formaldehyde ratio of about 1 :2.5 molar. The resulting solution is boiled under reflux for 1 hour. Butanol (1.5-2.0 mole per mole of urea) is then added together with a little xylene. The latter forms, with butanol and water, a ternary azeotrope which on distillation yields a condensate separating into an upper organic layer and a lower aqueous layer. By discarding the lower layer and returning the upper layer to the reactor, water is progressively removed from the system. After a substantial proportion of the water has been removed, an acid catalyst (e.g. phosphoric acid or phthalic anhydride) is added and heating is continued. When the required degree of reaction is attained, the solution is neutralized and concentrated to the desired solids content.

Air & Water Reactions

The solution gives up formaldehyde vapors readily. These vapors are flammable over a wide vapor-air concentration range. Water soluble.

Reactivity Profile

FORMALDEHYDE, SOLUTION, reacts violently with strong oxidizing agents (hydrogen peroxide, performic acid, perchloric acid in the presence of aniline, potassium permanganate, nitromethane). Reacts with bases (sodium hydroxide, potassium hydroxide, ammonia), and with nitrogen dioxide (explosive reaction around 180°C). Reacts with hydrochloric acid to form highly toxic bis(chloromethyl) ether. Polymerization reaction with phenol may develop sudden destructive pressure [Bretherick, 5th ed., 1995, p.168].

Hazard

Moderate fire risk. Explosive limits in air 7– 73%. Toxic by inhalation, strong irritant, a carcinogen. (Solution) Avoid breathing vapor and avoid skin contact. Confirmed carcinogen.

Health Hazard

Formaldehyde is moderately toxic by skin contact and inhalation. Exposure to formaldehyde gas can cause irritation of the eyes and respiratory tract, coughing, dry throat, tightening of the chest, headache, a sensation of pressure in the head, and palpitations of the heart. Exposure to 0.1 to 5 ppm causes irritation of the eyes, nose, and throat; above 10 ppm severe lacrimation occurs, burning in the nose and throat is experienced, and breathing becomes difficult. Acute exposure to concentrations above 25 ppm can cause serious injury, including fatal pulmonary edema. Formaldehyde has low acute toxicity via the oral route. Ingestion can cause irritation of the mouth, throat, and stomach, nausea, vomiting, convulsions, and coma. An oral dose of 30 to 100 mL of 37% formalin can be fatal in humans. Formalin solutions can cause severe eye burns and loss of vision. Eye contact may lead to delayed effects that are not appreciably eased by eye washing.Formaldehyde is regulated by OSHA as a carcinogen (Standard 1910.1048) and is listed in IARC Group 2A ("probable human carcinogen"). This substance is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Prolonged or repeated exposure to formaldehyde can cause dermatitis and sensitization of the skin and respiratory tract. Following skin contact, a symptom free period may occur in sensitized individuals. Subsequent exposures can then lead to itching, redness, and the formation of blisters

Fire Hazard

Toxic vapors such as carbon dioxide and carbon monoxide are generated during combustion. Explosion hazard: when aqueous formaldehyde solutions are heated above their flash points, a potential for explosion hazard exists. High formaldehyde concentration or methanol content lowers flash point. Reacts with nitrogen oxides at about 180; the reaction becomes explosive. Also reacts violently with perchloric acid-aniline, performic acid, nitromethane, magnesium carbonate, and hydrogen peroxide. When heated, irritant formaldehyde gas evolved from solution. The main products of decomposition are carbon monoxide and hydrogen. Metals such as platinum, copper, chromia, and alumina also catalyze the formation of methanol, methylformate, formic acid, carbon dioxide, and methane. Reacts with peroxide, nitrogen oxide, and performic acid causing explosions. Can react with hydrogen chloride or other inorganic chlorides to form bis-chloromethylether (BCME), a known carcinogen. Very reactive, combines readily with many substances, 40% solution is powerful reducing agent. Incompatible with amines, azo compounds, dithiocarbamates, alkali and alkaline earth metals, nitrides, nitro compounds, unsaturated aliphatics and sulfides, organic peroxides, oxidizing agents, and reducing agents. Aqueous solutions are unstable. Commercial formaldehyde-alcohol solutions are stable. Gas is stable in absence of water. Avoid oxidizing and alkaline materials. Hazardous polymerization may occur. Compound will polymerize with active organic materials such as phenol. Will polymerize violently in the presence of caustics and nitrides; (amines) exothermic reaction, (Azo compound) exothermic reaction giving off nitrogen gas, (caustics) heat generation and violent polymerization, (dithiocarbamates) formation of flammable gases and toxic fumes, formation of carbon disulfide may result, (alkali and alkaline earth metals) heat generation and formation of a flammable hydrogen gas.

Flammability and Explosibility

Formaldehyde gas is extremely flammable; formalin solution is a combustible liquid (NFPA rating = 2 for 37% formaldehyde (15% methanol), NFPA rating = 4 for 37% formaldehyde (methanol free)). Toxic vapors may be given off in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight formaldehyde fires.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Trade name

DYNOFORM?; FANNOFORM?; FORMALITH?; FORMOL?; FYDE?; HERCULES 37 M6-8?; HOCH?; IVALON?; KARSAN?; LYSOFORM?; MAGNIFLOC 156C FLOCCULANT?; MORBICID?; STERIFORM?; SUPERLYSOFORM?

Contact allergens

Sources and uses of formaldehyde are numerous. Exposed people are mainly health workers, cleaners, painters, met alworkers, but also photographers (color developers) and carbonless copy paper users. Formaldehyde can induce contact urticaria. Formaldehyde may be the cause of sen sitization to formaldehyde releasers: benzylhemiformal, bromonitrodioxane, bromonitropropanediol (?), chloroal lylhexaminium chloride or Quaternium-15, diazolidinylu rea, dimethylol urea, dimethyloldimethylhydantoin or DMDM hydantoin, hexamethylenetetramine or methe namine, imidazolidinylurea, monomethyloldimethylhy dantoin or MDM hydantoin, N-methylolchloracetamide, paraformaldehyde and trihydroxyethylhexahydrotriazine or Grotan BK. Formaldehyde is used for the synthesis of many resins. Some of them, such as formaldehyde-urea and melamine formaldehyde resins, can be used in textiles and second arily release free formaldehyde (see Chap. 40). Other resins, such as p-tert-butylphenol formalde hyde resin or tosylamine formaldehyde resin, do not release formaldehyde.

Biochem/physiol Actions

Formaldehyde is the simplest aldehyde that denatures the bihelical regions of RNA and converts the polynucleotides into random coils. It is a genotoxic substance that significantly induces DNA-protein crosslinks (DPC), sister-chromatid exchanges, micronuclei formation and leads to cytotoxicity. It also induces tumors in the nasal epithelium of rats and supposed to be a human carcinogen.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by ingestion. Experimental poison by ingestion, skin contact, inhalation, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by inhalation: lachqmation, olfactory changes, aggression, and pulmonary changes. Experimental reproductive effects. Human mutation data reported. A human skin and eye irritant. If swallowed it causes violent vomiting and darrhea that can lead to collapse. Frequent or prolonged exposure can cause hypersensitivity leading to contact dermatitis, possibly of an eczematoid nature. An air concentration of 20 ppm is quickly irritating to eyes. A common air contaminant. Flammable liquid when exposed to heat or flame; can react vigorously with oxidizers. A moderate explosion hazard when exposed to heat or flame. The gas is a more dangerous fire hazard than the vapor. Should formaldehyde be involved in a fire, irritating gaseous formaldehyde may be evolved. When aqueous formaldehyde solutions are heated above their flash points, a potential for an explosion hazard exists. High formaldehyde concentration or methanol content lowers the flash point. Reacts with sodum hydroxide to yield formic acid and hydrogen. Reacts with NOx at about 180'; the reaction becomes explosive. Also reacts violently with perchloric acid + anhe, performic acid, nitromethane, magnesium carbonate, H2O2. Moderately dangerous because of irritating vapor that may exist in toxic concentrations locally if storage tank is ruptured. To fight fire, stop flow of gas (for pure form); alcohol foam for 37% methanol-free form. When heated to decomposition it emits acrid smoke and fumes. See also ALDEHYDES.

Potential Exposure

Formaldehyde has found wide indus trial usage as a fungicide, germicide; and in disinfectants and embalming fluids. It is also used in the manufacture of artificial silk and textiles, latex, phenol, urea, thiourea and melamine resins; dyes, and inks; cellulose esters and other organic molecules; mirrors, and explosives. It is also used in the paper, photographic, and furniture industries. It is an intermediate in drug manufacture and is a pesticide intermediate.

Carcinogenicity

Formaldehyde is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans and supporting data on mechanisms of carcinogenesis. Formaldehyde was first listed in the Second Annual Report on Carcinogens in 1981 as reasonably anticipated to be a human carcinogen based on sufficient evidence from studies in experimental animals. Since that time, additional cancer studies in humans have been published, and the listing status was changed to known to be a human carcinogen in the Twelfth Report on Carcinogens (2011).

Source

Formaldehyde naturally occurs in jimsonweed, pears, black currant, horsemint, sago cycas seeds (1,640 to 2,200 ppm), oats, beets, and wild bergamot (Duke, 1992). Formaldehyde was formed when acetaldehyde in the presence of oxygen was subjected to continuous irradiation (λ >2200 ?) at room temperature (Johnston and Heicklen, 1964). Schauer et al. (2001) measured organic compound emission rates for volatile organic compounds, gas-phase semi-volatile organic compounds, and particle phase organic compounds from the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emission rates of formaldehyde were 1,165 mg/kg of pine burned, 759 mg/kg of oak burned, and 599 mg/kg of eucalyptus burned. Gas-phase tailpipe emission rates from California Phase II reformulated gasoline-powered automobiles with and without catalytic converters were 8.69 and 884 mg/km, respectively (Schauer et al., 2002).

Environmental Fate

Biological. Biodegradation products reported include formic acid and ethanol, each of which can further degrade to carbon dioxide (Verschueren, 1983).Photolytic. Major products reported from the photooxidation of formaldehyde with nitrogen oxides are carbon monoxide, carbon dioxide and hydrogen peroxide (Altshuller, 1983). In synthetic air, photolysis of formaldehyde gave hydrochloric acid andIrradiation of gaseous formaldehyde containing an excess of nitrogen dioxide over chlorine yielded ozone, carbon monoxide, nitrogen pentoxide, nitryl chloride, nitric acid and hydrochloric acid. Peroxynitric acid was the major photolysis product when chloChemical/Physical. Oxidizes in air to formic acid (Hartley and Kidd, 1987). Trioxymethylene may precipitate under cold temperatures (Sax, 1984). Polymerizes easily (Windholz et al., 1983). Anticipated products from the reaction of formaldehyde with ozone orhydroxyl radicals in air are carbon monoxide and carbon dioxide (Cupitt, 1980). Major products reported from the photooxidation of formaldehyde with nitrogen oxides are carbon monoxide, carbon dioxide and hydrogen peroxide (Altshuller, 1983).Reacts with hydrochloric acid in moist air forming bis(chloromethyl)ether. This compound may also form from an acidic solution containing chloride ion and formaldehyde (Frankel et al., 1974). In an aqueous solution at 25°C, nearly all the formaldehyde add

storage

work with formaldehyde should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact. Formaldehyde should be used only in areas free of ignition sources. Containers of formaldehyde should be stored in secondary containers in areas separate from oxidizers and bases.

Shipping

UN1198 Formaldehyde solutions, flammable, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner. UN2209 Formaldehyde solutions, with not<25% formal dehyde, Hazard class: 8; Labels: 8-Corrosive material. UN3077 For solids containing varying amounts of formal dehyde : UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Purification Methods

It commonly contains added MeOH. Add KOH solution (1 mole KOH: 100 moles HCHO) to ~37% by weight aqueous formaldehyde solution (formalin), or evaporate to dryness, to give paraformaldehyde polymer which, after washing with water, is dried in a vacuum desiccator over P2O5 or H2SO4. Formaldehyde is regenerated by heating the paraformaldehyde to 120o under vacuum, or by decomposing it with barium peroxide. The monomer, a colourless flammable gas, is passed through a glass-wool filter cooled to -48o in a CaCl2/ice mixture to remove particles of polymer, then dried by passage over P2O5 and either condensed in a bulb immersed in liquid nitrogen or absorbed in ice-cold conductivity water. The gas or aqueous solutions have pungent suffocating odours, are LACHRYMATORY and suspected carcinogens, handle carefully. Formalin is a disinfectant and a preservative of dead animal and plant tissues. [Beilstein 1 IV 3017.]

Toxicity evaluation

The carbonyl atom is the electrophilic site of formaldehyde, making it react easily with nucleophilic sites on cell membranes and in body fluids and tissues such as the amino groups in protein and DNA. Higher concentrations of formaldehyde precipitate protein. It is probable that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, allowing the unmetabolized intact molecule to exert its effects locally. Formaldehyde is a very strong crosslinking agent even in the low concentration range. The reaction mechanism of this agent is the initial addition of formaldehyde to a primary amine on either an amino acid residue or DNA base to yield a hydroxymethyl intermediate. Then the hydroxymethyl group condenses with a second primary amine to yield a methylene bridge.

Incompatibilities

Pure formaldehyde may polymerize unless properly inhibited (usually with methanol). May form explosive mixture with air. Incompatible with strong acids; amines, strong oxidizers; alkaline materials; nitrogen dioxide; performic acid; phenols, urea. Reaction with hydrochloric acid forms bis-chloromethyl ether, a carcino gen. Formalin is incompatible with strong oxidizers, alkalis, acids, phenols, urea, oxides, isocyanates, caustics, anhydrides.

Waste Disposal

Return refillable compressed gas cylinders to supplier. Incineration in solution of combus tible solvent. Consult with environmental regulatory agen cies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, trans portation, treatment, and waste disposal.

Check Digit Verification of cas no

The CAS Registry Mumber 50-00-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 0 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 50-00:
(4*5)+(3*0)+(2*0)+(1*0)=20
20 % 10 = 0
So 50-00-0 is a valid CAS Registry Number.
InChI:InChI=1/CH2O/c1-2/h1H2

50-00-0 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (F0622)  Formaldehyde Solution (37%) (stabilized with Methanol)  

  • 50-00-0

  • 300mL

  • 130.00CNY

  • Detail
  • Alfa Aesar

  • (33314)  Formaldehyde, 37% in aq. soln., ACS, 36.5-38.0%, stab. with 10-15% methanol   

  • 50-00-0

  • 500ml

  • 306.0CNY

  • Detail
  • Alfa Aesar

  • (33314)  Formaldehyde, 37% in aq. soln., ACS, 36.5-38.0%, stab. with 10-15% methanol   

  • 50-00-0

  • 1L

  • 491.0CNY

  • Detail
  • Alfa Aesar

  • (33314)  Formaldehyde, 37% in aq. soln., ACS, 36.5-38.0%, stab. with 10-15% methanol   

  • 50-00-0

  • 4L

  • 1166.0CNY

  • Detail
  • Alfa Aesar

  • (33314)  Formaldehyde, 37% in aq. soln., ACS, 36.5-38.0%, stab. with 10-15% methanol   

  • 50-00-0

  • *4x1L

  • 1730.0CNY

  • Detail
  • Alfa Aesar

  • (33314)  Formaldehyde, 37% in aq. soln., ACS, 36.5-38.0%, stab. with 10-15% methanol   

  • 50-00-0

  • *4x4L

  • 3232.0CNY

  • Detail
  • Alfa Aesar

  • (A16163)  Formaldehyde, 37% w/w aq. soln., stab. with 7-8% methanol   

  • 50-00-0

  • 100ml

  • 207.0CNY

  • Detail
  • Alfa Aesar

  • (A16163)  Formaldehyde, 37% w/w aq. soln., stab. with 7-8% methanol   

  • 50-00-0

  • 500ml

  • 244.0CNY

  • Detail
  • Alfa Aesar

  • (A16163)  Formaldehyde, 37% w/w aq. soln., stab. with 7-8% methanol   

  • 50-00-0

  • 2500ml

  • 409.0CNY

  • Detail
  • Supelco

  • (47083-U)  Formaldehydesolution  stabilized with methanol, ~37 wt. % in H2O, analytical standard

  • 50-00-0

  • 47083-U

  • 368.55CNY

  • Detail
  • Sigma-Aldrich

  • (15513)  Formaldehydesolution  meets analytical specification of Ph.?Eur., BP, 35 wt. %, contains 10% methanol as stabilizer

  • 50-00-0

  • 15513-1L-R

  • 391.95CNY

  • Detail

50-00-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Formaldehyde

1.2 Other means of identification

Product number -
Other names superlysoform

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Formaldehyde is used predominantly as a chemical intermediate. It also has minor uses in agriculture, as an analytical reagent, in concrete and plaster additives, cosmetics, disinfectants, fumigants, photography, and wood preservation. One of the most common uses of formaldehyde in the U.S is manufacturing urea-formaldehyde resins, used in particleboard products. Formaldehyde (as urea formaldehyde foam) was extensively used as an insulating material until 1982 when it was banned by the U.S. Consumer Product Safety Commission.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50-00-0 SDS

50-00-0Synthetic route

methanol
67-56-1

methanol

formaldehyd
50-00-0

formaldehyd

Conditions
ConditionsYield
With PQQTME; calcium perchlorate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile Oxidation;100%
at 370℃; under 760.051 Torr; for 1h; Reagent/catalyst; Temperature; Inert atmosphere; Flow reactor;100%
With sulfuric acid Electrochemical reaction;100%
2-quinolin-2-yl-ethanol
1011-50-3

2-quinolin-2-yl-ethanol

A

2-methylquinoline
91-63-4

2-methylquinoline

B

formaldehyd
50-00-0

formaldehyd

Conditions
ConditionsYield
In benzene Ambient temperature; Irradiation;A 100%
B 100%
phenylethane 1,2-diol
93-56-1

phenylethane 1,2-diol

4-cyano-N,N-dimethylaniline-N-oxide
62820-00-2

4-cyano-N,N-dimethylaniline-N-oxide

A

formaldehyd
50-00-0

formaldehyd

B

4-cyano-N-methylaniline
4714-62-9

4-cyano-N-methylaniline

C

benzaldehyde
100-52-7

benzaldehyde

D

4-cyano-N,N-dimethylaniline
1197-19-9

4-cyano-N,N-dimethylaniline

Conditions
ConditionsYield
With chloro(5,10,15,20-tetraphenylporphyrinato)chromium(III) In acetonitrile for 0.666667h; Rate constant; Ambient temperature; Irradiation; oxygen transfer was investigated, different irradiation time;A n/a
B n/a
C 100%
D 100%
2-(2-deuterioxyethyl)quinoline
29166-01-6

2-(2-deuterioxyethyl)quinoline

A

formaldehyd
50-00-0

formaldehyd

B

2-(monodeuteriomethyl)quinoline

2-(monodeuteriomethyl)quinoline

Conditions
ConditionsYield
In benzene Ambient temperature; Irradiation;A 100%
B 100%
sarcosine
107-97-1

sarcosine

A

formaldehyd
50-00-0

formaldehyd

B

carbon dioxide
124-38-9

carbon dioxide

C

methylamine
74-89-5

methylamine

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; sodium perchlorate; chlorine at 24.9℃; Mechanism; Rate constant; Equilibrium constant; multistep reaction: 1.) water, 298 deg K, 2.) water, 298 deg K; reactions under var. conditions;A 100%
B n/a
C n/a
N-chloro-sarcosine
52316-59-3

N-chloro-sarcosine

A

formaldehyd
50-00-0

formaldehyd

B

methylamine
74-89-5

methylamine

Conditions
ConditionsYield
In water at 24.9℃; Rate constant; Mechanism; Thermodynamic data; Irradiation; I=0.5 mol-1 L-1; various pH; ΔH(excit.), ΔS(excit.);A 100%
B n/a
With water In 1,4-dioxane at 25℃;
With water In 1,4-dioxane at 25℃; Kinetics; Mechanism;
benzenesulfinyl-benzoyloxy-methane
41065-20-7

benzenesulfinyl-benzoyloxy-methane

A

formaldehyd
50-00-0

formaldehyd

B

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
With potassium hydroxide In methanolA 100%
B 61%
p-nitro-N,N-dimethylaniline-N-oxide
26492-31-9

p-nitro-N,N-dimethylaniline-N-oxide

A

formaldehyd
50-00-0

formaldehyd

B

N,N-Dimethyl-4-nitroaniline
100-23-2

N,N-Dimethyl-4-nitroaniline

Conditions
ConditionsYield
With 1H-imidazole; meso-tetraphenylporphyrin iron(III) chloride; DMA-OCH3 In chloroform at 25℃; for 0.5h;A n/a
B 100%
C6H16NO4P
85437-83-8

C6H16NO4P

A

formaldehyd
50-00-0

formaldehyd

B

trans-nitrosomethane dimer
2717-67-1, 17606-84-7, 37765-15-4

trans-nitrosomethane dimer

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid for 2h;A n/a
B 100%
((bis(dimethylamino)phosphinyl)oxy)dimethylamine
85437-82-7

((bis(dimethylamino)phosphinyl)oxy)dimethylamine

A

formaldehyd
50-00-0

formaldehyd

B

trans-nitrosomethane dimer
2717-67-1, 17606-84-7, 37765-15-4

trans-nitrosomethane dimer

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid for 2h;A n/a
B 100%
With 3-chloro-benzenecarboperoxoic acid for 2h;A n/a
B 100%
1-(3,4-Dihydro-benzo[c][1,2]oxazin-1-yl)-2-methyl-propan-1-one
180985-69-7

1-(3,4-Dihydro-benzo[c][1,2]oxazin-1-yl)-2-methyl-propan-1-one

A

formaldehyd
50-00-0

formaldehyd

B

2-isopropyl-4H-3,1-benzoxazine
115975-92-3

2-isopropyl-4H-3,1-benzoxazine

Conditions
ConditionsYield
In 1,3,5-trimethyl-benzene Heating;A n/a
B 100%
(H2O)5Cr(CH2OCH3)(2+)
78402-17-2

(H2O)5Cr(CH2OCH3)(2+)

chromium (III) ion

chromium (III) ion

formaldehyd
50-00-0

formaldehyd

Conditions
ConditionsYield
With water; mercury ion In water Kinetics; byproducts: MeOH, H(1+); excess of Hg(2+) soln. (mol. ratio of Hg(2+)/Cr-compd. 2:1) added to soln. of Cr-compd. at 24.8°C under N2 by controlled ionic strength;Co(NH3)5F has no effect; not sepd., detected by UV;100%
(H2O)5CrCH2OH(2+)

(H2O)5CrCH2OH(2+)

chromium (III) ion

chromium (III) ion

formaldehyd
50-00-0

formaldehyd

Conditions
ConditionsYield
With mercury ion In methanol; water Kinetics; byproducts: H(1+); excess of Hg(2+) soln. (mol. ratio of Hg(2+)/Cr-compd. 2:1) added to soln. of Cr-compd. in 1 M aq. MeOH at 24.8°C under N2 by controlledionic strength; Co(NH3)5F and typ of alcohols has no effect; not sepd., detected by UV;100%
Dimethyl ether
115-10-6

Dimethyl ether

A

formaldehyd
50-00-0

formaldehyd

B

Methyl formate
107-31-3

Methyl formate

Conditions
ConditionsYield
With nitrogen; oxygen at 239.84℃; Conversion of starting material;A 99.7%
B 0.3%
With nitrogen; oxygen at 239.84℃; Conversion of starting material;A 98.8%
B 1.2%
With nitrogen; oxygen at 239.84℃; Conversion of starting material;A 98.6%
B 1.4%
methane
34557-54-5

methane

dinitrogen monoxide
10024-97-2

dinitrogen monoxide

A

methanol
67-56-1

methanol

B

formaldehyd
50-00-0

formaldehyd

C

carbon dioxide
124-38-9

carbon dioxide

D

carbon monoxide
201230-82-2

carbon monoxide

E

nitrogen
7727-37-9

nitrogen

Conditions
ConditionsYield
In neat (no solvent) Kinetics; Oxidation of CH4 by N2O in presence of catalyst (773 K): deposited Cu(2+) on carbon;;A 0.2%
B 0.3%
C 99.5%
D 0%
E n/a
In neat (no solvent) Kinetics; byproducts: C2H5OH (small quantity); oxidation of CH4 by N2O in presence of catalyst (773 K): deposited Ti(4+) on carbon;;A 13.8%
B 0%
C 86.2%
D 0%
E n/a
In neat (no solvent) Kinetics; Oxidation of CH4 by N2O in presence of catalyst (773 K): deposited Co(2+) on carbon;;A 0%
B 0%
C 75%
D 25%
E n/a
6,10b-dimethyl-4a,10b-dihydro-3H-naphtho<2,1-e><1,2,4>trioxine
89946-44-1

6,10b-dimethyl-4a,10b-dihydro-3H-naphtho<2,1-e><1,2,4>trioxine

A

formaldehyd
50-00-0

formaldehyd

(1S,2R)-1,4-Dimethyl-1,2-dihydro-naphthalene-1,2-diol
114390-56-6

(1S,2R)-1,4-Dimethyl-1,2-dihydro-naphthalene-1,2-diol

Conditions
ConditionsYield
With acetic acid; zinc at 16℃; for 0.25h;A n/a
B 99%
tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

2,2'-azinobis-(3-ethyl-2,3-dihydrobenzothiazole-6-sulphonate) diammonium salt
30931-67-0

2,2'-azinobis-(3-ethyl-2,3-dihydrobenzothiazole-6-sulphonate) diammonium salt

A

methanol
67-56-1

methanol

B

formaldehyd
50-00-0

formaldehyd

C

C18H18N4O6S4(1+)*2H3N

C18H18N4O6S4(1+)*2H3N

D

acetone
67-64-1

acetone

E

tert-butyl alcohol
75-65-0

tert-butyl alcohol

Conditions
ConditionsYield
Fe(III)T4MPyP In water at 30℃; Rate constant; Kinetics; Mechanism; the catalyst Fe(III)T4MPyP is 5,10,15,20-tetra(N-methyl-4-pyridyl)-porphyrinatoiron(III) pentachloride; pH 9.2; investigation of the dependence of velocity constant on ionic strength, pH and t-butyl hydroperoxide concentration;A 3%
B n/a
C 72%
D 4%
E 98%
Dimethyl-p-toluidine
99-97-8

Dimethyl-p-toluidine

A

formaldehyd
50-00-0

formaldehyd

B

N-methyl-p-toluidine
623-08-5

N-methyl-p-toluidine

Conditions
ConditionsYield
With {Ru(IV)O(2,2`-bipyridine)(PEt3)}(ClO4)2 In acetonitrile at 21℃; Rate constant; Kinetics; Thermodynamic data; other Ru(IV) complex catalyst, ΔH(excit), ΔS(excit) determined;A n/a
B 98%
With iron 5,10,15,20-tetrakis(2,4,6-trimethylphenyl)porphyrin; 3-chloro-benzenecarboperoxoic acid; 3-chlorobenzoate In dichloromethane at -50.1℃; Rate constant; also horseradish peroxidase and H2O2 as reagents; kinetic isotope effect; var. temp. and solvents;
With dihydrogen peroxide; sodium tartrate; 5,10,15,20-Ph4-21H,23H-porphine-p,p',p'',p'''-(SO4)4*FeCl3 In water; acetonitrile at 25℃; pH=4; oxidative N-demethylation;A n/a
B 10 % Chromat.
amyl nitrate
1002-16-0

amyl nitrate

A

formaldehyd
50-00-0

formaldehyd

B

pentan-1-ol
71-41-0

pentan-1-ol

C

n-butane
106-97-8

n-butane

D

NO2

NO2

Conditions
ConditionsYield
In tetralin at 154℃; Mechanism; Kinetics; Ea, log A, ΔH(activation), volume of activation; other solvents, other temperatures;A n/a
B 98%
C 2%
D n/a
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
70458-96-7

1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

A

formaldehyd
50-00-0

formaldehyd

B

ammonia
7664-41-7

ammonia

C

6-fluoro-7-amino-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
75001-63-7

6-fluoro-7-amino-1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
With potassium permanganate; cetyltrimethylammonim bromide; acetic acid In water; acetonitrile at 24.84℃; Kinetics; Catalytic behavior; Mechanism; Thermodynamic data; Activation energy; Temperature; Concentration; Solvent; UV-irradiation;A n/a
B n/a
C 98%
1-phenyl-2-piperidin-1-yl-ethanone
779-52-2

1-phenyl-2-piperidin-1-yl-ethanone

A

N-Formylpiperidine
2591-86-8

N-Formylpiperidine

B

formaldehyd
50-00-0

formaldehyd

C

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide In ethanolA 14%
B n/a
C 96%
With dihydrogen peroxide In ethanolA 14%
B n/a
C 94%
[2-(2-[1,3]Dithian-2-yl-1-methyl-ethoxymethoxy)-ethyl]-trimethyl-silane
76513-61-6

[2-(2-[1,3]Dithian-2-yl-1-methyl-ethoxymethoxy)-ethyl]-trimethyl-silane

A

formaldehyd
50-00-0

formaldehyd

B

ethene
74-85-1

ethene

C

trimethylsilyl fluoride
420-56-4

trimethylsilyl fluoride

D

2-(2-hydroxypropyl-1')-1,3-dithiane
14950-49-3

2-(2-hydroxypropyl-1')-1,3-dithiane

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In N,N,N,N,N,N-hexamethylphosphoric triamide at 45℃; for 5h;A n/a
B n/a
C n/a
D 96%
methanol
67-56-1

methanol

A

formaldehyd
50-00-0

formaldehyd

B

Dimethyl ether
115-10-6

Dimethyl ether

Conditions
ConditionsYield
molybdenum(VI) oxide In gas at 290 - 350℃; under 750.06 Torr; Thermodynamic data; Product distribution; structure sensitive oxidation with orthorhomb. or microcrystalline MoO3, further temperatures, activation energy EA;A 95%
B 5%
With oxygen; aluminophosphate zeolite at 300℃; Product distribution; temperature, without oxygen, effect of catalysts;
With oxygen; vanadia at 300 - 600℃; Product distribution; further catalysts;
2-(N,N-dimethylaminomethyl)pyrrole
14745-84-7

2-(N,N-dimethylaminomethyl)pyrrole

A

formaldehyd
50-00-0

formaldehyd

B

N-Nitrosodimethylamine
62-75-9

N-Nitrosodimethylamine

C

maleimidemonooxime
74230-05-0

maleimidemonooxime

Conditions
ConditionsYield
With sodium nitrite In water at 25℃; for 0.05h; Product distribution; Mechanism; variation of amount of reagent and reaction period;A n/a
B 95%
C n/a
With sodium nitrite In water; acetic acid at 25℃; for 0.05h;A n/a
B 95%
C n/a
With sodium nitrite In water; acetic acid at 25℃;
methanol
67-56-1

methanol

(4-methoxyphenoxy)methyl 2-iodobenzoate

(4-methoxyphenoxy)methyl 2-iodobenzoate

A

benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

B

formaldehyd
50-00-0

formaldehyd

C

4-methoxy-phenol
150-76-5

4-methoxy-phenol

Conditions
ConditionsYield
With potassium carbonate at 40℃; for 1.5h; Schlenk technique;A 95%
B n/a
C 90%
morpholine
110-91-8

morpholine

bromonitromethane
563-70-2

bromonitromethane

A

N-nitrosomorpholine
59-89-2

N-nitrosomorpholine

B

formaldehyd
50-00-0

formaldehyd

Conditions
ConditionsYield
In acetonitrile at 70℃; for 168h;A 94%
B n/a
lithium 2-nitropropane
3958-63-2

lithium 2-nitropropane

diphenyliodonium bromide
1483-73-4

diphenyliodonium bromide

A

formaldehyd
50-00-0

formaldehyd

B

iodobenzene
591-50-4

iodobenzene

C

biphenyl
92-52-4

biphenyl

D

2,3-dimethyl-2,3-dinitrobutane
3964-18-9

2,3-dimethyl-2,3-dinitrobutane

E

2-nitro-2-phenylpropane
3457-58-7

2-nitro-2-phenylpropane

F

benzene
71-43-2

benzene

Conditions
ConditionsYield
In methanol at 30℃; for 48h; Mechanism; Product distribution; other diaryliodonium bromides, other times, effect of light and oxygen;A 38%
B 94%
C 5%
D 5%
E 41%
F 43%
lithium 2-nitropropane
3958-63-2

lithium 2-nitropropane

diphenyliodonium bromide
1483-73-4

diphenyliodonium bromide

A

formaldehyd
50-00-0

formaldehyd

B

iodobenzene
591-50-4

iodobenzene

C

2-nitro-2-phenylpropane
3457-58-7

2-nitro-2-phenylpropane

D

benzene
71-43-2

benzene

Conditions
ConditionsYield
In methanol at 30℃; for 48h; Further byproducts given;A 38%
B 94%
C 41%
D 43%
N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

A

formaldehyd
50-00-0

formaldehyd

B

N-methylaniline
100-61-8

N-methylaniline

Conditions
ConditionsYield
With {Ru(IV)O(2,2`-bipyridine)(PPh3)}(ClO4)2 In acetonitrile at 21℃; Rate constant; Kinetics; Thermodynamic data; other Ru(IV) complex catalyst, ΔH(excit), ΔS(excit) determined;A n/a
B 94%
With dihydrogen peroxide; FePp In ethanol at 38℃; for 0.166667h; Product distribution; borate buffer, pH 9; further educts;
With phosphate buffer; dihydrogen peroxide; cytochrome c at 30℃; Equilibrium constant; Rate constant; also in the presence of phosphate bilayer;
C17H30B2O2

C17H30B2O2

formaldehyd
50-00-0

formaldehyd

Conditions
ConditionsYield
In water-d2 for 0.5h;94%
piperidine
110-89-4

piperidine

Succinimide
123-56-8

Succinimide

formaldehyd
50-00-0

formaldehyd

N-piperidinomethyl-succinimide
13314-95-9

N-piperidinomethyl-succinimide

Conditions
ConditionsYield
With aluminum oxide In water for 0.2h; Condensation; microwave irradiation;100%
With ethanol; water
morpholine
110-91-8

morpholine

Succinimide
123-56-8

Succinimide

formaldehyd
50-00-0

formaldehyd

N-[{morpholin-1-yl}-methyl]-pyrrolidine-2,5-dione
13314-97-1

N-[{morpholin-1-yl}-methyl]-pyrrolidine-2,5-dione

Conditions
ConditionsYield
With aluminum oxide In water for 0.2h; Condensation; microwave irradiation;100%
In ethanol at 60℃; for 2h;88%
morpholine
110-91-8

morpholine

formaldehyd
50-00-0

formaldehyd

4-methyl-morpholine
109-02-4

4-methyl-morpholine

Conditions
ConditionsYield
With oxalic acid at 100 - 120℃; Eschweiler-Clarke methylation;100%
With hydrogen In methanol at 100℃; under 9750.98 Torr; for 3h; Autoclave;97%
With acetic acid at 30℃; for 2h;96%
phenyl benzyl ketone
451-40-1

phenyl benzyl ketone

formaldehyd
50-00-0

formaldehyd

1,2-diphenylprop-2-en-1-one
4452-11-3

1,2-diphenylprop-2-en-1-one

Conditions
ConditionsYield
With piperidine; acetic acid In methanol Inert atmosphere; Reflux;100%
With trifluoroacetic acid; diisopropylamine 2,2,2-trifluoroacetic acid salt In tetrahydrofuran for 2h; Reflux;88%
With piperidine; acetic acid In methanol; water for 6h; Reflux;88%
indole
120-72-9

indole

formaldehyd
50-00-0

formaldehyd

indole-3-carbinol
700-06-1

indole-3-carbinol

Conditions
ConditionsYield
With sodium methylate for 8h; Heating;100%
With methanol; sodium hydrogencarbonate
With sodium methylate
pyrrole
109-97-7

pyrrole

formaldehyd
50-00-0

formaldehyd

(1H-pyrrole-2,5-diyl)dimethanol
6249-04-3

(1H-pyrrole-2,5-diyl)dimethanol

Conditions
ConditionsYield
With potassium carbonate In water at 5℃; for 168h;100%
With sodium hydroxide for 3h; Ambient temperature;46.4%
With potassium carbonate In water at 5℃; for 168h; Inert atmosphere; Sealed flask; Darkness;32%
formaldehyd
50-00-0

formaldehyd

diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

ethyl 2-diethoxyphosphinoylacrylate
20345-61-3

ethyl 2-diethoxyphosphinoylacrylate

Conditions
ConditionsYield
Stage #1: formaldehyd; diethoxyphosphoryl-acetic acid ethyl ester With piperidine In methanol at 80℃; for 36h;
Stage #2: With toluene-4-sulfonic acid In toluene for 16h; Dean-Stark; Reflux;
100%
Stage #1: formaldehyd With piperidine In methanol for 0.5h; Heating;
Stage #2: diethoxyphosphoryl-acetic acid ethyl ester In methanol for 70h; Heating;
73%
piperidine In methanol Heating;60%
formaldehyd
50-00-0

formaldehyd

ephedrine
299-42-3

ephedrine

(-)-N-methylephedrine
552-79-4

(-)-N-methylephedrine

Conditions
ConditionsYield
With HCOOH (98percent) In water for 18h; Heating;100%
With formic acid at 80℃; for 0.0666667h; Microwave irradiation; Neat (no solvent);90%
With formic acid at 65℃; for 6h;89%
formaldehyd
50-00-0

formaldehyd

ephedrine
299-42-3

ephedrine

(4S,5R)-3,4-dimethyl-5-phenyl-1,3-oxazolidine
123618-06-4

(4S,5R)-3,4-dimethyl-5-phenyl-1,3-oxazolidine

Conditions
ConditionsYield
for 1h; Ambient temperature;100%
With potassium carbonate In benzene for 6h; Heating;93%
With sodium sulfate; potassium hydroxide In methanol for 6h; Reflux;85%
formaldehyd
50-00-0

formaldehyd

cyanuric acid
108-80-5

cyanuric acid

1,3,5-tri(hydroxymethyl)-1,3,5-triaza-2,4,6-cyclohexanetrione
10471-40-6

1,3,5-tri(hydroxymethyl)-1,3,5-triaza-2,4,6-cyclohexanetrione

Conditions
ConditionsYield
In water100%
In pyridine; water for 15h; Ambient temperature;90%
formaldehyd
50-00-0

formaldehyd

ethanolamine
141-43-5

ethanolamine

1,3,5-tris(2-hydroxyethyl)-1,3,5-triazacyclohexane
4719-04-4

1,3,5-tris(2-hydroxyethyl)-1,3,5-triazacyclohexane

Conditions
ConditionsYield
In methanol at 20℃; for 16h;100%
In methanol for 48h;86%
With water
In ethanol Cyclization;
at 50 - 80℃; for 1h;92 g
formaldehyd
50-00-0

formaldehyd

ethanolamine
141-43-5

ethanolamine

N-(hydroxyethyl)aminomethanesulfonic acid
88788-08-3

N-(hydroxyethyl)aminomethanesulfonic acid

Conditions
ConditionsYield
Stage #1: formaldehyd; ethanolamine In water at 10℃; for 24h;
Stage #2: With sulfur dioxide In water at 20℃; pH=<= 1.0;
100%
With water und anschliessende Saettigung mit SO2;
formaldehyd
50-00-0

formaldehyd

4-acetaminophenol
103-90-2

4-acetaminophenol

diethylamine
109-89-7

diethylamine

N-{3-[(diethylamino)methyl]-4-hydroxyphenyl}acetamide
121-78-8

N-{3-[(diethylamino)methyl]-4-hydroxyphenyl}acetamide

Conditions
ConditionsYield
In ethanol at 80℃; for 1.5h; Microwave irradiation;100%
In ethanol for 12h; Heating;80%
In ethanol at 80℃; for 1h; Microwave irradiation;77%
formaldehyd
50-00-0

formaldehyd

diethylamine
109-89-7

diethylamine

phenylacetylene
536-74-3

phenylacetylene

diethyl-(3-phenyl-prop-2-ynyl)-amine
22396-72-1

diethyl-(3-phenyl-prop-2-ynyl)-amine

Conditions
ConditionsYield
With copper dichloride at 80℃; under 150.015 Torr; for 3h; Mannich reaction;100%
With silver nitrate at 105℃; for 0.133333h; microwave irradiation;99%
copper(l) iodide In water; dimethyl sulfoxide at 30℃; for 10h;98%
formaldehyd
50-00-0

formaldehyd

aniline
62-53-3

aniline

1,3,5-triphenylhexahydro-1,3,5-triazine
91-78-1

1,3,5-triphenylhexahydro-1,3,5-triazine

Conditions
ConditionsYield
In toluene at 120℃; for 0.5h;100%
With triethylamine In ethanol; water at 25℃; for 0.25h; Mannich Aminomethylation; Sonication; Irradiation;98%
With PEG-400 for 0.0833333h; Catalytic behavior;95%
formaldehyd
50-00-0

formaldehyd

uracil
66-22-8

uracil

5-hydroxymethyl uracil
4433-40-3

5-hydroxymethyl uracil

Conditions
ConditionsYield
With potassium hydroxide In water at 50 - 52℃; for 68h;100%
With potassium hydroxide for 0.05h; microwave irradiation;98%
With potassium hydroxide In water at 0 - 55℃; for 36h;98%
formaldehyd
50-00-0

formaldehyd

urethane
51-79-6

urethane

ethyl N-(hydroxymethyl)carbamate
5027-16-7

ethyl N-(hydroxymethyl)carbamate

Conditions
ConditionsYield
With potassium carbonate In benzene at 70 - 75℃; for 3.5h;100%
With barium dihydroxide In water for 40h; Ambient temperature;38%
With barium dihydroxide
formaldehyd
50-00-0

formaldehyd

ethanethiol
75-08-1

ethanethiol

(ethylthio)methanol
15909-30-5

(ethylthio)methanol

Conditions
ConditionsYield
With sodium hydroxide; water at 25 - 40℃; for 1h; Addition;100%
With water
for 2h; Ambient temperature;
formaldehyd
50-00-0

formaldehyd

diethyl malonate
105-53-3

diethyl malonate

diethyl bis(hydroxymethyl)malonate
20605-01-0

diethyl bis(hydroxymethyl)malonate

Conditions
ConditionsYield
With potassium carbonate In water at 20℃;100%
With triethylamine In tetrahydrofuran; 1,4-dioxane; water a) from 4 deg C to 6 deg C, 20 min, b) RT, 40 min;96%
With hydrogenchloride; sodium carbonate In water at 15 - 20℃; under 100 Torr; pH=6-7; Large scale;90%
formaldehyd
50-00-0

formaldehyd

L-Tryptophan
73-22-3

L-Tryptophan

3-carboxy-1,2,3,4-tetrahydro-2-carboline
42438-90-4

3-carboxy-1,2,3,4-tetrahydro-2-carboline

Conditions
ConditionsYield
With sulfuric acid Pictet-Spengler condensation;100%
With sulfuric acid In water Pictet-Spengler condensation;100%
With sulfuric acid under 750.075 Torr; Pictet-Spengler cyclization; Inert atmosphere;100%
N-methyl-acetamide
79-16-3

N-methyl-acetamide

formaldehyd
50-00-0

formaldehyd

N-methyl-N-chloromethylacetamide
4270-65-9

N-methyl-N-chloromethylacetamide

Conditions
ConditionsYield
With chloro-trimethyl-silane for 2h; Heating;100%
With chloro-trimethyl-silane for 1h; Heating;64%
(i), (ii) PCl5, dioxane; Multistep reaction;
dibutyl hydrogen phosphite
1809-19-4

dibutyl hydrogen phosphite

formaldehyd
50-00-0

formaldehyd

dibutyl (hydroxymethyl)phosphonate
24630-66-8

dibutyl (hydroxymethyl)phosphonate

Conditions
ConditionsYield
With potassium carbonate In cyclohexane at 20℃; for 48h; Inert atmosphere;100%
triethylamine In toluene at 60℃; for 3h;89.1%
With triethylamine at 90℃; for 16h; Inert atmosphere;76.3%
formaldehyd
50-00-0

formaldehyd

Beta-pinene
177698-19-0

Beta-pinene

nopol
128-50-7

nopol

Conditions
ConditionsYield
With iron(III) phosphate In acetonitrile at 80℃; for 4h; Prins condensation;100%
With mesoporous SnSBA-15(5) In toluene at 89.84℃; for 6h; Prins reaction;96.7%
at 150℃;61%
formaldehyd
50-00-0

formaldehyd

2,2-dimethyl-3-butyne
917-92-0

2,2-dimethyl-3-butyne

4,4-dimethylpent-2-yn-1-ol
52323-98-5

4,4-dimethylpent-2-yn-1-ol

Conditions
ConditionsYield
Stage #1: 3,3-Dimethylbut-1-yne With n-butyllithium In tetrahydrofuran at 0 - 20℃;
Stage #2: formaldehyd In tetrahydrofuran at 20 - 65℃; for 17h;
Stage #3: With water In ethyl acetate
100%
Stage #1: 3,3-Dimethylbut-1-yne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: formaldehyd In tetrahydrofuran; hexane at -78 - 20℃; for 1h;
98%
With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78 - 20℃; for 2h;97%
formaldehyd
50-00-0

formaldehyd

L-alanin
56-41-7

L-alanin

N,N-dimethyl-L-alanine
2812-31-9

N,N-dimethyl-L-alanine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 20h;100%
With 10 mol% palladium on carbon; hydrogen In water at 20℃; under 760.051 Torr; for 36.5h; Reflux;99%
With sodium dihydrogenphosphate; zinc at 30℃; for 20h;92%
formaldehyd
50-00-0

formaldehyd

L-leucine
61-90-5

L-leucine

(S)-2-dimethylamino-4-methyl-pentanoic acid
2439-37-4

(S)-2-dimethylamino-4-methyl-pentanoic acid

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In water; acetonitrile at 22℃; for 1h; pH=Ca.7; Inert atmosphere;100%
With sodium dihydrogenphosphate; zinc at 30℃; for 20h;95%
With sodium tetrahydroborate In 2,2,2-trifluoroethanol for 48h; Reflux;88%
formaldehyd
50-00-0

formaldehyd

n-octyne
629-05-0

n-octyne

2-nonyn-1-ol
5921-73-3

2-nonyn-1-ol

Conditions
ConditionsYield
Stage #1: n-octyne With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 1h; Inert atmosphere;
Stage #2: formaldehyd In tetrahydrofuran; hexane at -78 - 20℃; for 16h; Inert atmosphere;
100%
Stage #1: n-octyne With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h;
Stage #2: formaldehyd In diethyl ether; hexane at 20℃;
98%
Stage #1: n-octyne With n-butyllithium In diethyl ether; hexane at -78℃; Inert atmosphere;
Stage #2: formaldehyd In diethyl ether; hexane at -78 - 20℃; for 14.5h; Inert atmosphere;
88%
formaldehyd
50-00-0

formaldehyd

1,2,4,5-tetramethylbenzene
95-93-2

1,2,4,5-tetramethylbenzene

1,4-bis(chloromethyl)-2,3,5,6-tetramethylbenzene
3022-16-0

1,4-bis(chloromethyl)-2,3,5,6-tetramethylbenzene

Conditions
ConditionsYield
Stage #1: formaldehyd; 1,2,4,5-tetramethylbenzene With hydrogenchloride; sodium chloride In water at 120℃; for 5h;
Stage #2: With zinc(II) chloride In water for 24h; Reflux;
100%
With hydrogenchloride; sodium chloride In water at 120℃; for 31h;91%
With hydrogenchloride; zinc(II) chloride at 90℃; for 9h;26%
formaldehyd
50-00-0

formaldehyd

benzyloxyacetoaldehyde
60656-87-3

benzyloxyacetoaldehyde

2-(benzyloxy)acrylaldehyde
62222-04-2

2-(benzyloxy)acrylaldehyde

Conditions
ConditionsYield
With pyrrolidine In dichloromethane; water at 45℃; for 1h;100%
With L-proline In water; N,N-dimethyl-formamide at 50℃; for 8h;99%
With pyrrolidine; propionic acid In water; isopropyl alcohol at 45℃; for 4h;98%

50-00-0Relevant articles and documents

Oxidation of methane and ethylene in water at ambient conditions

Sorokin,Kudrik,Alvarez,Afanasiev,Millet,Bouchu

, p. 149 - 154 (2010)

Available spectroscopic, labelling and reactivity data show that stable μ-nitrido diiron phthalocyanine activates H2O2 to form a high-valent diiron oxo species. This species is a very powerful oxidant which oxidizes methane in pure water at 25-60 °C to methanol, formaldehyde and formic acid. The catalytic activity can significantly be increased in the presence of a diluted acid solution. Thus, a high turnover number of 209 was attained in 0.075 M H2SO4. Oxidation of ethylene resulted in the formation of formic acid as a major product and formaldehyde with high turnover numbers. Under optimal conditions, 426 mol HCOOH and 37 mol CH 2O per mole of catalyst were obtained in pure water. The practical and green features of this novel approach (H2O2 as the clean oxidant, water as the clean reaction medium, easily accessible solid catalyst) as well as the relevance to biological oxidation (binuclear structure of bio-inspired complex) are of great importance both from practical and fundamental points of view.

Partial Oxidation of Methane by Nitrous Oxide over Molybdenum Oxide supported on Silica

Liu, R.-S.,Iwamoto, M.,Lunsford, Jack H.

, p. 78 - 79 (1982)

Methanol and formaldehyde were formed as major products at a moderate conversion level (16percent) in the partial oxidation of methane by nitrous oxide in the presence of water over molybdenum oxide supported on silica.

Flash Photolysis Study of the CH3O2 + CH3O2 Reaction: Rate Constants and Branching Ratios from 248 to 573 K

Lightfoot, P. D.,Lesclaux, R.,Veyret, B.

, p. 700 - 707 (1990)

The reactions 2CH3O2 -> 2CH3O + O2 (1a), 2CH3O2 -> CH3OH + HCHO + O2 (1b), and 2CH3O2 -> CH3COOH + O2 (1c) have been studied at temperatures between 248 and 573 K.At temperature above 373 K, the resulting decay traces were distorted away from pure second order at short wavelenghts (around 210 nm), owing to the presence of the hydroperoxy radicals formed via the nonterminating pathway (1a) and the subsequent rapid step CH3O + O2 -> HCHO + HO2 (2).This distortion enabled the nonterminating/terminating branching ratio, β, to be determined.Combining the present resultswith previously published work on the branching ratios gave lnβ=3.80-1470/T.Thus, although reaction 1 acts as a termination reaction under atmospheric conditions, it largely serves to convert CH3O2 into HO2 under combustion conditions.The temperature dependence of β enabled the real constant for the reaction k1, to be obtained over the entire experimental temperature range, giving k1 = 1.3E-13exp(365/T)cm31/molecule1/s, with ?2A/cm6molecule-2s-2 = 2.00E-28, ?2E/R/K2 = 1712, and ?2AE/R/cm3molecule-1s-1 = -5.61E-13.Absolute uncertainties, including contributions from both the experimental measurements and the dependence of k1 on various analysis parameters, are estimated to be 22percent, independent of temperature.No dependence of either the branching ratio or k1 on the total pressure was found.The mechanism of the title reaction is discussed and the present results are compared with existing studies of alkylperoxy self-reactions.The implications for combustion and atmospheric modeling are also discussed.

Epidoxoform: A hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells

Taatjes, Dylan J.,Fenick, David J.,Koch, Tad H.

, p. 1306 - 1314 (1998)

The recent discovery that the formaldehyde conjugates of doxorubicin and daunorubicin, Doxoform and Daunoform, are cytotoxic to resistant human breast cancer cells prompted the search for hydrolytically more stable anthracycline-formaldehyde conjugates. Doxoform and Daunoform consist of two molecules of the parent drug bound together with three methylene groups, two forming oxazolidine rings and one binding the oxazolidines together at their 3'amino nitrogens. The 4'-epimer of doxorubicin, epidoxorubicin, reacts with formaldehyde at its amino alcohol functionality to produce a conjugate, Epidoxoform, in 59% yield whose structure consists of two molecules of epidoxorubicin bound together with three methylene groups in a 1,6-diaza- 4,9-dioxabicyclo[4.4.1]undecane ring system. The structure was established from spectroscopic data and is consistent with products from reaction of simpler vicinal trans-amino alcohols with formaldehyde. Epidoxoforrn hydrolyzes at pH 7.3 to an equilibrium mixture with dimeric and monomeric epidoxorubicin-formaldehyde conjugates without release of formaldehyde or epidoxorubicin. The hydrolysis follows the rate law (A mutually implies B) mutually implies C + D where A (Epidoxoform) is in rapid equilibrium with B, and B is in slow equilibrium with C and D. The forward rate constant for A/B going to C+D gives a half-life of approximately 2 h at 37 °C. At equilibrium the mixture is stable for at least 2 days. At pH 6.0, hydrolysis proceeds with first-order kinetics to epidoxorubicin and formaldehyde with a half- life of 15 min at 37 °C. Epidoxoform and epidoxorubicin plus formaldehyde react with the self-complementary DNA octamer (GC)4 to yield five drug-DNA adducts which have structures analogous to the doxorubicin-DNA adducts from reaction of Doxoform with (GC)4. Epidoxoform is 3-fold more toxic to MCF-7 human breast cancer cells and greater than 120-fold more toxic to MCF-7/ADR resistant cells than epidoxorubicin. Epidoxoform in equilibrium with its hydrolysis products is greater than 25-fold more toxic to resistant cells with respect to epidoxorubicin.

The rate of homolysis of adducts of peroxynitrite to the C=O double bond

Merenyi,Lind,Goldstein

, p. 40 - 48 (2002)

Nucleophilic addition of the peroxynitrite anion, ONOO-, to the two prototypical carbonyl compounds, acetaldehyde and acetone, was investigated in the pH interval 7.4-14. The process is initiated by fast equilibration between the reactants and the corresponding tetrahedral adduct anion, the equilibrium being strongly shifted to the reactant side. The adduct anion also undergoes fast protonation by water and added buffers. Consequently, the rate of the bimolecular reaction between ONOO- and the carbonyl is strongly dependent on the pH and on the concentration of the buffer. The pKa of the carbonyl-ONOO adduct was estimated to be 11.8 and 12.3 for acetone and acetaldehyde, respectively. It is shown that both the anionic and the neutral adducts suffer fast homolysis along the weak O-O bond to yield free alkoxyl and nitrogen dioxide radicals. The yield of free radicals was determined to be about 15% with both carbonyl compounds at low and high pH, while the remainder collapses to molecular products in the solvent cage. The rate constants for the homolysis of the adducts vary from ca. 3 x 105 to ca. 5 x 106 s-1, suggesting that they cannot act as oxidants in biological systems. This small variation around a mean value of about 106 s-1 suggests that the O-O bond in the adduct is rather insensitive to its protonation state and to the nature of its carbonyl precursor. An overall reaction scheme was proposed, and all the corresponding rate constants were evaluated. Finally, thermokinetic considerations were employed to argue that the formation of dioxirane as an intermediate in the reaction of ONOO- with acetone is an unlikely process.

Atmospheric sink of β-ocimene and camphene initiated by Cl atoms: Kinetics and products at NOx free-Air

Gaona-Colmán, Elizabeth,Blanco, María B.,Barnes, Ian,Wiesen, Peter,Teruel, Mariano A.

, p. 27054 - 27063 (2018)

Rate coefficients for the gas-phase reactions of Cl atoms with β-ocimene and camphene were determined to be (in units of 10-10 cm3 per molecule per s) 5.5 ± 0.7 and 3.3 ± 0.4, respectively. The experiments were performed by the relative technique in an environmental chamber with FTIR detection of the reactants at 298 K and 760 torr. Product identification experiments were carried out by gas chromatography with mass spectrometry detection (GC-MS) using the solid-phase microextraction (SPME) method employing on-fiber carbonyl compound derivatization with o-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine hydrochloride. An analysis of the available rates of addition of Cl atoms and OH radicals to the double bond of alkenes and cyclic and acyclic terpenes with a conjugated double bond at 298 K is presented. The atmospheric persistence of these compounds was calculated taking into account the measured rate coefficients. In addition, tropospheric chemical mechanisms for the title reactions are postulated.

Kinetics of the Reaction of Vinyl Radical with Molecular Oxygen

Knyazev, Vadim D.,Slagle, Irene R.

, p. 2247 - 2249 (1995)

The kinetics of the reaction C2H3 + O2 -> products (reaction 1) has been studied at temperatures 299-1005 K and He densities (3-18)E16 molecule cm-3 using laser photolysis/photoionization mass spectrometry.Rate constants were determined in time-resolved experiments as a function of temperature and bath gas density.The overall rate constant of reaction 1 is independent of pressure within the experimental range and can be described by the Arrhenius expression k1 = (6.92 +/- 0.17)E-12 exp(120 +/- 12 K)/T) cm3 molecule-1 s-1.Experimental results are compared with theoretical predictions, and implications for the mechanism of reaction 1 are discussed.

O(1D) reaction with cyclopropane: Evidence of O atom insertion into the C-C bond

Shu, Jinian,Lin, Jim J.,Wang, Chia C.,Lee, Yuan T.,Yang, Xueming,Nguyen, Thanh Lam,Mebel, Alexander M.

, p. 7 - 10 (2001)

The reaction kinetics of O(1D) with cyclopropane was investigated using the universal crossed molecular beam method. The detailed dynamics of this reaction was explained from the analysis of time of flight spectra and angular distribution of th

Ab initio study on the unimolecular decomposition mechanisms and spectroscopic properties of CH3OF

Apeloig, Yitzhak,Albrecht, Karsten

, p. 9564 - 9569 (1995)

High-level ab initio calculations of the structure, vibrational frequencies, and NMR spectra of the recently isolated methyl hypofluorite, CH3OF, have been carried out. When electron correlation is included in the calculations (but not at the HF level), there is a very good agreement between the experimental and the theoretical IR and NMR spectra. Four different unimolecular decomposition pathways, all leading to CH2O and HF, were studied. Of these, two mechanisms, the synchronous single-step HF elimination and a two-step mechanism via the CH3O? and F? radicals, are predicted to be the most favorable, both having activation free energies of ca. 38 kcal mol-1 at GAUSSIAN 2. A theoretical analysis of the expected kinetic isotope effects between the competing pathways leads to a clear differentiation which can be used in experimental studies.

The Retardation of Methanol Oxidation at a Platinum Electrode in an Acid Solution

Matsui, Hiroshi

, p. 3295 - 3300 (1988)

The rate retardation of the oxidation of methanol at the potential range of about 0.65-0.8 V vs. a reversible hydrogen electrode on a platinum electrode in 0.5 mol dm-3 H2SO4 was studied.The rate retardation of the overall oxidation was caused by that of the oxidation, Reaction D, not via COad.From the relationship among the rate of Reaction D, the COad coverage, and the potentials, three types of rate retardation were found out: Type 1-Reaction D is not accelerated by the potential, and the rate of the reaction is determined by the COad coverage and the methanol concentration.Type 2- the rate of Reaction D decreases at stationary COad coverages as the oxidation is prolonged.Type 3- the rate decreases at COad coverages close to the limiting value.It is proposed that Types 1 and 2 of the rate retardations take place when the adsorption of methanol molecules is rate-determining, and when the formaldehyde and formic acid formed from methanol are accumulated in the vicinity of the electrode, respectively.Type 3 of the rate retardation has been explained in a preceding paper in terms of the aggregate damaging effect of COad.

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