- Total synthesis of (+)-sorangicin A
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(Chemical Equation Presented) The final synthetic challenges associated with (+)-sorangicin A have been overcome, thus leading to the first total synthesis of this complex macrolide antibiotic. Highlights of the highly convergent synthesis include two Jul
- Smith III, Amos B.,Dong, Shuzhi,Brenneman, Jehrod B.,Fox, Richard J.
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supporting information; experimental part
p. 12109 - 12111
(2010/01/30)
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- Antibiotics from Gliding Bacteria, XLII. Chemical Modification of Sorangicin A and Structure - Activity Relationship I: Carboxyl and Hydroxyl Group Derivatives
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The synthesis of selectively protected sorangicin A derivatives and their application in the modification of the hydroxyl groups and the carboxyl group in sorangicin A (1) is described.Esters, amides, and sorangicins modified at the hydroxyl groups were prepared and their activities against Staphylococcus aureus, Escherichia coli, and their in vitro inhibition of RNA polymerase were examined.Although no sorangicin A derivatives with superior biological activity were observed, some derivatives completely retained their antibiotic activity or were slightly improved in their activity with certain strains.
- Jansen, Rolf,Schummer, Dietmar,Irschik, Herbert,Hoefle, Gerhard
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p. 975 - 988
(2007/10/02)
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