100415-25-6Relevant academic research and scientific papers
Total synthesis of (+)-sorangicin A
Smith III, Amos B.,Dong, Shuzhi,Brenneman, Jehrod B.,Fox, Richard J.
supporting information; experimental part, p. 12109 - 12111 (2010/01/30)
(Chemical Equation Presented) The final synthetic challenges associated with (+)-sorangicin A have been overcome, thus leading to the first total synthesis of this complex macrolide antibiotic. Highlights of the highly convergent synthesis include two Jul
Antibiotics from Gliding Bacteria, XLII. Chemical Modification of Sorangicin A and Structure - Activity Relationship I: Carboxyl and Hydroxyl Group Derivatives
Jansen, Rolf,Schummer, Dietmar,Irschik, Herbert,Hoefle, Gerhard
, p. 975 - 988 (2007/10/02)
The synthesis of selectively protected sorangicin A derivatives and their application in the modification of the hydroxyl groups and the carboxyl group in sorangicin A (1) is described.Esters, amides, and sorangicins modified at the hydroxyl groups were prepared and their activities against Staphylococcus aureus, Escherichia coli, and their in vitro inhibition of RNA polymerase were examined.Although no sorangicin A derivatives with superior biological activity were observed, some derivatives completely retained their antibiotic activity or were slightly improved in their activity with certain strains.
