- A kind of dual role of analgesic of the center of the new compound, preparation method and use thereof
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The invention relates to a central-analgesic novel compound having double effects, or a pharmaceutical salt or a hydrate thereof, a preparation method of the novel compound and an application of the novel compound in drugs. The compound is represented as
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Paragraph 0071-0072
(2017/10/22)
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- A synthetic hydrochloric acid he spurts he number of method
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The invention discloses a method for synthesizing tapentadol hydrochloride. The method comprises a reaction route shown in the specification. In the reaction route, R1 is one of halogens, -OH, -OR4, -NO2, -NH2, -NR5R6, -SH and -SR7. A required chiral isomer is directly obtained through a reaction under chiral catalysis, so the method has the advantages of avoiding of problems of a large amount of wastes and environmental protection due to chiral splitting, short route, simple operation, easy industrialization, high raw material utilization rate, great improvement of the yield, cost reduction, meeting of requirements of industrial production of tapentadol hydrochloride, and significant progress.
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Paragraph 0086; 0087
(2017/08/25)
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- PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1ETHYL-2-METHYLPROPYL]PHENOL
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The present invention relates to an improved process for the preparation of 3- [(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.
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Page/Page column 10
(2008/06/13)
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