1004545-97-4

Basic information

• Product Name: 2-Amino-3-hydroxybenzaldehyde
• Synonyms: 2-Amino-3-hydroxybenzaldehyde;Benzaldehyde, 2-amino-3-hydroxy-
• CAS NO: 1004545-97-4
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.13598
• Mol File: 1004545-97-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-Amino-3-hydroxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-hydroxybenzaldehyde(1004545-97-4)
• EPA Substance Registry System: 2-Amino-3-hydroxybenzaldehyde(1004545-97-4)

Safety Data

• Hazardous Substances Data: 1004545-97-4(Hazardous Substances Data)

Usage

Derivative of

Benzaldehyde

Functional groups

Amino group (-NH2), Hydroxyl group (-OH)

Common uses

Intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds

Biological and pharmacological activities

Antioxidant, antimicrobial

Potential therapeutic applications

Studied for the development of new drugs for various medical conditions

Valuable building block

Due to its chemical structure and properties, it serves as a valuable building block for the synthesis of biologically active compounds.

Upstream product

• 42123-33-1 3-hydroxy-2-nitrobenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 1004545-76-9 2-amino-3-(1-hydroxybut-3-enyl)phenol 
• 15599-52-7 5,7-dibromo-2-methylquinolin-8-ol 
• 826-81-3 2-methyl-8-quinolinol 
• 75457-13-5 8-hydroxy-3-methylquinoline 
• 111470-98-5 3-ethyl-8-hydroxyquinoline 
• 457948-80-0 C₁₆H₁₃NO 
• 457948-81-1 C₁₆H₁₁Br₂NO 
• 6961-25-7 2-phenyl-8-hydroxy-quinoline 

Relevant articles and documents

A Phytochemical-Halogenated Quinoline Combination Therapy Strategy for the Treatment of Pathogenic Bacteria

With the continued rise of drug-resistant bacterial infections coupled with the current discouraging state of the antibiotic pipeline, the need for new antibacterial agents that operate through unique mechanisms compared with conventional antibiotics and work in synergy with other agents is at an all-time high. We have discovered that gallic acid, a plant-derived phytochemical, dramatically potentiates the antibacterial activities of several halogenated quinolines (up to 11 800-fold potentiation against Staphylococcus aureus) against pathogenic bacteria, including drug-resistant clinical isolates. S. aureus demonstrated the highest sensitivity towards gallic acid-halogenated quinoline combinations, including one halogenated quinoline that demonstrated potentiation of biofilm eradication activity against a methicillin-resistant S. aureus (MRSA) clinical isolate. During our studies, we also demonstrated that these halogenated quionlines operate through an interesting metal(II) cation-dependent mechanism and display promising mammalian cytotoxicity.

Microwave-enhanced Friedl?nder synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and tolerant bacteria

Herein, we disclose the development of a catalyst- and protecting-group-free microwave-enhanced Friedl?nder synthesis which permits the single-step, convergent assembly of diverse 8-hydroxyquinolines with greatly improved reaction yields over traditional oil bath heating (increased from 34% to 72%). This rapid synthesis permitted the discovery of novel biofilm-eradicating halogenated quinolines (MBECs = 1.0-23.5 μM) active against MRSA, MRSE, and VRE. These small molecules exhibit activity through mechanisms independent of membrane lysis, further demonstrating their potential as a clinically useful treatment option against persistent biofilm-associated infections.

COMBINATION THERAPY FOR TREATING INFECTIONS DISEASES

The present invention provides compositions comprising a quinoline, a potentiating agent, and optionally a pharmaceutically acceptable carrier, for treating and/or preventing infectious diseases. The provided compositions may also include another therapeutic agent (e.g., antibiotic). The provided compositions may be useful in treating and/or preventing bacterial infections as well as inhibiting and eradicating biofilm formation.

A facile synthesis of 2-methylquinolines via Pd-catalyzed aza-Wacker oxidative cyclization

(Chemical Equation Presented) A novel Pd-catalyzed Wacker-type oxidative cyclization under air is described. By using this cyclization, a series of 2-methylquinolines are readily prepared with good yields under mild conditions.