826-81-3Relevant articles and documents
Tassel, J. H. Van,Wendlandt, W. W.
, p. 4821 - 4823 (1960)
Nickel-Catalyzed Dehydrogenation of N-Heterocycles Using Molecular Oxygen
Banerjee, Debasis,Bera, Atanu,Bera, Sourajit
supporting information, (2020/09/02)
Herein, an efficient and selective nickel-catalyzed dehydrogenation of five- and six-membered N-heterocycles is presented. The transformation occurs in the presence of alkyl, alkoxy, chloro, free hydroxyl and primary amine, internal and terminal olefin, trifluoromethyl, and ester functional groups. Synthesis of an important ligand and the antimalarial drug quinine is demonstrated. Mechanistic studies revealed that the cyclic imine serves as the key intermediate for this stepwise transformation.
Method of preparing 8-hydroxy-2-methylquinoline by utilizing chlorquinaldol waste residues
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Paragraph 0026-0027; 0029-0030; 0032-0033; 0034-0036; 0038-0, (2018/09/11)
The invention belongs to the technical field of organic waste residue recovery and particularly relates to a method of preparing 8-hydroxy-2-methylquinoline by utilizing chlorquinaldol waste residues.The method comprises the following steps of in the presence of an acid binding agent, utilizing a hydrogenation catalyst to catalyze the chlorquinaldol waste residues, filtering the chlorquinaldol waste residues after catalytic hydrogenation, keeping a solid, performing dissolution with an acid liquid, regulating a pH value of a solution, then performing extraction, keeping an organic phase, andperforming drying and distillation to prepare the 8-hydroxy-2-methylquinoline. For the method provided by the invention, by using palladium-carbon hydroxide as the high-activity hydrogenation catalyst, deficiency of catalysts such as palladium on carbon, raney nickel and platinum on carbon to the reaction activity of a chlorinated product on a conjugate ring and harsh reaction conditions of high temperature, high pressure and the like are avoided, so that reaction is liable to control, the production period is short, and industrialization is liable.
Assembly of Diversely Substituted Quinolines via Aerobic Oxidative Aromatization from Simple Alcohols and Anilines
Li, Jixing,Zhang, Jinlong,Yang, Huameng,Jiang, Gaoxi
supporting information, p. 3284 - 3290 (2017/03/23)
An aerobic oxidative aromatization of simple aliphatic alcohols and anilines under the Pd(OAc)2/2,4,6-Collidine/Br?nsted acid catalytic system has been established, providing a direct approach for the preparation of diverse substituted quinoline derivatives in high yields with wide functional group tolerance. Practically, the protocol can be easily scaled up to gram-scale and was utilized in the concise formal synthesis of a promising herbicide candidate.