Absolute Configuration of (-)-5-Benzoyl-1,2-dihydro-3H-pyrroloa>pyrrole-1-carboxylic Acid, the Active Enantiomer of Ketorolac
The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrroloa>pyrrole-1-carboxylic acid (1) is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.
Guzman, Angel,Yuste, Francisco,Toscano, Ruben A.,Young, John M.,Horn, Albert R. Van,Muchowski, Joseph M.