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100488-87-7

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, characterized by its ability to inhibit aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has minimal effects on platelet aggregation induced by other agents such as arachidonic acid, ADP, or collagen. CV-6209 is a bioavailable compound, as demonstrated by its ability to prevent PAF-induced hypotension in rats without blocking hypotension triggered by other substances like arachidonic acid, histamine, bradykinin, or isoproterenol. This pale-yellow solid is utilized in the study of PAF receptor signaling in both in vitro and in vivo settings.

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  • 1-ethyl-2-{[N-({2-methoxy-3-[(octadecylcarbamoyl)oxy]propoxy}carbonyl)acetamido]methyl}pyridin-1-ium chloride

    Cas No: 100488-87-7

  • USD $ 1.9-2.9 / Gram

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  • 100488-87-7 Structure

  • Basic information

    1. Product Name: CV-6209
    2. Synonyms: 2-(2-Acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl- pyridinium Chloride;2-(N-Acetyl-N-(2-methoxy-3-octadecylcarbamoyloxypropoxycarbonyl)aminomethyl)-1-ethylpyridinium;Cv 6209 chloride;Pyridinium, 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-, chloride
    3. CAS NO:100488-87-7
    4. Molecular Formula: C34H60ClN3O6
    5. Molecular Weight: 642.3097
    6. EINECS: N/A
    7. Product Categories: Heterocyclic Compounds;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 100488-87-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. Stability: Store at -200C.
    10. CAS DataBase Reference: CV-6209(CAS DataBase Reference)
    11. NIST Chemistry Reference: CV-6209(100488-87-7)
    12. EPA Substance Registry System: CV-6209(100488-87-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 100488-87-7(Hazardous Substances Data)

100488-87-7 Usage

Uses

1. Used in Pharmaceutical Research:
CV-6209 is used as a competitive PAF receptor antagonist for studying the role of PAF receptor signaling in various biological processes and diseases.
2. Used in Platelet Aggregation Inhibition:
CV-6209 is used as an inhibitor of PAF-induced human platelet aggregation, which can be beneficial in understanding and treating conditions related to abnormal platelet aggregation.
3. Used in Cardiovascular Research:
CV-6209 is used to inhibit PAF-induced hypotension and lethality in rats, providing insights into the management of cardiovascular conditions associated with PAF receptor activation.
4. Used in Toxicology and Safety Studies:
CV-6209 is employed to investigate the effects of PAF receptor antagonism on hypotension triggered by various substances, such as arachidonic acid, histamine, bradykinin, or isoproterenol, which can be crucial in assessing the safety and potential side effects of PAF receptor antagonists in drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 100488-87-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,4,8 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 100488-87:
(8*1)+(7*0)+(6*0)+(5*4)+(4*8)+(3*8)+(2*8)+(1*7)=107
107 % 10 = 7
So 100488-87-7 is a valid CAS Registry Number.
InChI:InChI=1/C34H59N3O6.ClH/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-25-35-33(39)42-28-32(41-4)29-43-34(40)37(30(3)38)27-31-24-21-23-26-36(31)6-2;/h21,23-24,26,32H,5-20,22,25,27-29H2,1-4H3;1H

100488-87-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-<propoxy>carbonyl>amino>methyl>-1-ethylpyridinium chloride

1.2 Other means of identification

Product number -
Other names 2-{N-acetyl-N-[({2-methoxy-3-[(octadecylcarbamoyl)oxy]propoxy}carbonyl)amino]methyl}-1-ethylpyridinium chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100488-87-7 SDS

100488-87-7Downstream Products

100488-87-7Related news

Effects of the PAF-analog and -antagonist CV-6209 (cas 100488-87-7) on cultured human glioma cell lines07/29/2019

Cell lines of human glioma (U-343 MGa and U-251 MG) and human glia (U-533 CG) origin were cultured as monolayers and exposed to CV-6209, an alkyl-phospholipid analog and antagonist of platelet activating factor. This drug had very potent antiproliferative effects on the studied human glioma cell...detailed

100488-87-7Relevant articles and documents

Platelet activating factor antagonists: Synthesis and structure-activity studies of novel PAF analogues modified in the phosphorylcholine moiety

Takatani,Yoshioka,Tasaka,Terashita,Imura,Nishikawa,Tsushima

, p. 56 - 64 (2007/10/02)

New analogues of platelet activating factor (PAF), in which the phosphate and trimethylammonium moieties were replaced with an acylcarbamoyl moiety and a quaternary cyclic ammonium group, were synthesized. Their biological activities as PAF antagonists we

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