Halocyclization of Unsaturated Guanidines Mediated by Koser's Reagent and Lithium Halides
The synthesis of halogenated cyclic guanidines through iodine(III)-mediated umpolung of halide salts is described. Cyclic guanidines of various sizes can be obtained with generally excellent regioselectivities through either a chloro- or a bromocyclization, using Koser's reagent and the corresponding lithium salt.
Daniel, Marion,Blanchard, Florent,Nocquet-Thibault, Sophie,Cariou, Kevin,Dodd, Robert H.
p. 10624 - 10633
(2015/11/18)
Iodocyclisations reactions of Boc- and Cbz-protected N-allylguanidines
The cyclisation of mono-protected and bis-protected guanidines 8a-j under standard iodocyclisation conditions (I2/K2CO3) gave the guanidine heterocycles 9-25 via either a direct cyclisation or by a cyclisation/ring-contrac
Al Shuhaib, Zainab,Davies, Deiniol H.,Dennis, Mark,Evans, Daniel M.,Fletcher, Matthew D.,Franken, Herjan,Hancock, Paul,Hollinshead, Jackie,Jones, Iestyn,K?hm, Kristina,Murphy, Patrick J.,Nash, Robert,Potter, David,Rowles, Richard
p. 4412 - 4419
(2014/06/10)
Cyclisation reactions of bis-protected guanidines
The cyclisation of N-allyl- and N-homoallylguanidines using DMDO or I2/K2CO2 leading to novel heterocycles is reported.
Albrecht, Christiane,Barnes, Sarah,B?ckemeier, Henning,Davies, Deiniol,Dennis, Mark,Evans, Daniel M.,Fletcher, Matthew D.,Jones, Iestyn,Leitmann, Vera,Murphy, Patrick J.,Rowles, Richard,Nash, Robert,Stephenson, Richard A.,Horton, Peter N.,Hursthouse, Michael B.
p. 185 - 188
(2008/03/30)
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