Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity
H3R structure-activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules wi
Hudkins, Robert L.,Aimone, Lisa D.,Bailey, Thomas R.,Bendesky, Robert J.,Dandu, Reddeppa Reddy,Dunn, Derek,Gruner, John A.,Josef, Kurt A.,Lin, Yin-Guo,Lyons, Jacquelyn,Marcy, Val R.,Mathiasen, Joanne R.,Sundar, Babu G.,Tao, Ming,Zulli, Allison L.,Raddatz, Rita,Bacon, Edward R.
scheme or table
p. 5493 - 5497
(2011/10/12)
Pyridizinone derivatives
The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.
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Page/Page column 79
(2008/06/13)
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